ArticleScientific reports2018
Multivariate Granger causality unveils directed parietal to prefrontal cortex connectivity during task-free MRI.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mapping Whole-Brain Nonlinear Structure-Function Dynamics in Aging via Neural Granger Causality.Brain topography · 2026Article
- Functional Connectivity Between Human Motor and Somatosensory Areas During a Multifinger Tapping Task: A Proof-of-Concept Study.NeuroSci · 2026Article
- Coupling causality and interpretable machine learning to reveal the reaction coordinate of C-N coupling with a supramolecular Cu-calix[8]arene catalyst.Digital discovery · 2025Article
- DSAM: A deep learning framework for analyzing temporal and spatial dynamics in brain networks.Medical image analysis · 2025Article
- Heritability of human "directed" functional connectome.Brain and behavior · 2023Article
- NLGC: Network localized Granger causality with application to MEG directional functional connectivity analysis.NeuroImage · 2022Article
- Forecasting brain activity based on models of spatiotemporal brain dynamics: A comparison of graph neural network architectures.Network neuroscience (Cambridge, Mass.) · 2022Article
- Vibrotactile enhancement in hand rehabilitation has a reinforcing effect on sensorimotor brain activities.Frontiers in neuroscience · 2022Article
- Quantification of the effects of climatic conditions on French hospital admissions and deaths induced by SARS-CoV-2.Scientific reports · 2021Article
- Modeling brain connectivity dynamics in functional magnetic resonance imaging via particle filtering.Brain informatics · 2021Article
- [Multiple-scale intermuscular coupling network analysis].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Constructing Brain Connectivity Model Using Causal Network Reconstruction Approach.Frontiers in neuroinformatics · 2021Article
- Construction of functional brain connectivity networks from fMRI data with driving and modulatory inputs: an extended conditional Granger causality approach.AIMS neuroscience · 2020Article
- Converging Resting State Networks Unravels Potential Remote Effects of Transcranial Magnetic Stimulation for Major Depression.Frontiers in psychiatry · 2020Article
- Variability and Reproducibility of Directed and Undirected Functional MRI Connectomes in the Human Brain.Entropy (Basel, Switzerland) · 2019Article
- A Parsimonious Granger Causality Formulation for Capturing Arbitrarily Long Multivariate Associations.Entropy (Basel, Switzerland) · 2019Article
- Frequency-specific coupling in fronto-parieto-occipital cortical circuits underlie active tactile discrimination.Scientific reports · 2019Article
- Causal influence of brainstem response to transcutaneous vagus nerve stimulation on cardiovagal outflow.Brain stimulationArticle
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Authors and funding
6 authors.
Funding
Abstract
While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-based approach to estimating directed in-network interactions and quantify its advantages using extensive realistic synthetic BOLD data simulations to match Human Connectome Project (HCP) data specification. We then apply our framework to resting state functional MRI (rs-fMRI) data provided by the HCP to estimate the directed connectome of the human brain. We show that the functional interactions between parietal and prefrontal cortices commonly observed in rs-fMRI studies are not symmetrical, but consists of directional connectivity from parietal areas to prefrontal cortices rather than vice versa. These effects are localized within the same hemisphere and do not generalize to cross-hemispheric functional interactions. Our data are consistent with neurophysiological evidence that posterior parietal cortices involved in processing and integration of multi-sensory information modulate the function of more anterior prefrontal regions implicated in action control and goal-directed behaviour. The directionality of functional connectivity can provide an additional layer of information in interpreting rs-fMRI studies both in health and disease.
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