ArticleNature2018
Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.
Abstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
158 citing papers in PubMed, 259 citations in OpenAlex.
- Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study.BMC cancer · 2019Trial
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer patients.PLoS biology · 2026Article
- WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer.Cancer science · 2026Article
- Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation.Nature communications · 2026Article
- Investigation of the effects and underlying mechanisms of adenylate kinase 1 on inosine monophosphate deposition in Beijing-You chickens.Poultry science · 2026Article
- The moonlighting functions of glycolytic enzymes in tumorigenesis.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Glucose Metabolic Enzyme PFKFB3 in Cardiopulmonary Vascular Health and Disease.Circulation research · 2026Review
- Targeting phosphofructokinase in cancer: integrating natural products for metabolic reprogramming and therapeutic innovation.Frontiers in pharmacology · 2026Review
- Metabolic adaptations in cancer progression.Physiological reviews · 2026Review
- Non-canonical splice variant of PFKFB4 in hepatocellular carcinoma activates AKT through direct interaction.JHEP reports : innovation in hepatology · 2025Article
- Targeting phosphofructokinase 2 the isoform PFKFB4 suppresses glioblastoma proliferation and malignancy.Genes & genomics · 2025Article
- A novel protein cPFKFB4 encoded by hsa_circ_0065394 strengthens PKM2-mediated glucose metabolic reprogramming to facilitate pancreatic cancer progression under hypoxia.Molecular cancer · 2025Article
- Deciphering enemy tactics - the narrow path to an optimal anti-cancer strategy targeting the Warburg effect.Pharmacological reports : PR · 2025Review
- Metabolomics as a tool for understanding and treating triple-negative breast cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Landscape of metabolic alterations and treatment strategies in breast cancer.Genes & diseases · 2025Review
- Nuclear-localized metabolic enzymes: emerging key players in tumor epigenetic regulation.Molecular and cellular biochemistry · 2025Review
- Article
- Uridine as a hub in cancer metabolism and RNA biology.Experimental & molecular medicine · 2025Review
- PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate.Nature communications · 2025Article
98 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Subhamoy DasguptaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. subhamoy.dasgupta@roswellpark.org.
Kimal RajapaksheDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Bokai ZhuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Bryan C NikolaiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Ping YiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Nagireddy PutluriDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Jong Min ChoiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Sung Y JungVerna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
Cristian CoarfaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Thomas F WestbrookVerna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
Xiang H-F ZhangDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Charles E FouldsDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Sophia Y TsaiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Ming-Jer TsaiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Bert W O'MalleyDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. berto@bcm.edu.
Baylor College of Medicine · US
Funding
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MTranslational Research in Breast Cancer (SPORE)P50CA186784 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Xiang Zhang · 2014 to 2026
$24.5MTISSUE COACTIVATOR AND RECEPTOR EXPRESSION FINGERPRINTSP01DK059820 · NIDDK · INSTITUT DE GENETIQUE ET BIOLOGIE MOLECU · PI O'MALLEY, BERT W · 2001 to 2016
$23.1MSEX HORMONE RECEPTOR COMPONENTS AND THE CELL GENOMER01HD007857 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$14.6MRacial Disparity in Bladder Cancer and Identification of Altered Metabolism in African American Compare to European Bladder CancerR01CA220297 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PUTLURI, NAGIREDDY · 2017 to 2021
$1.8MINVESTIGATING THE ROLE OF THE TRANSCRIPTIONAL COREGULATOR SRC-2 IN CASTRATION RESISTANT PROSTATE CANCERK22CA207578 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI DASGUPTA, SUBHAMOY · 2017 to 2019
$620kNCI NIH HHS K22 CA207578NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA186784NCI NIH HHS R01 CA220297NICHD NIH HHS R01 HD007857NIDDK NIH HHS P01 DK059820NIH HHS HD08818
Abstract
Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that sustain rapid proliferation and metastasis
Indexed as
Gene Expression Regulation, NeoplasticTranscriptional ActivationActivating Transcription Factor 4AnimalsBreast NeoplasmsCell Line, TumorFemaleGlucoseGlycolysisHumansLung NeoplasmsMiceNeoplasm MetastasisNuclear Receptor Coactivator 3Pentose Phosphate PathwayPhosphofructokinase-2Activating Transcription Factor 4ATF4 protein, humanGlucoseNCOA3 protein, humanNuclear Receptor Coactivator 3PFKFB4 protein, humanPhosphofructokinase-2PhosphoserinepurinePurinesReceptors, EstrogenTransketolase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.