ArticleScientific reports2018
Simple Method for De Novo Structural Determination of Underivatised Glucose Oligosaccharides.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Unraveling Cross-Ring Dissociation Mechanisms of Hexoses in Collision-Induced Dissociation.The journal of physical chemistry. A · 2026Article
- De novo determination of fucose linkages in N-glycans using logically derived sequence tandem mass spectrometry.Glycoconjugate journal · 2026Article
- Isomeric diversity of GlcNAc(ManScientific reports · 2026Article
- Structural Analysis of Laminarin-Derived Oligosaccharides Produced by Transglycosylation of Exo-β-1,3-glucanase ScEXG1 fromJournal of agricultural and food chemistry · 2026Article
- The colostrum chronicles: identifying porcine milk oligosaccharides in colostrum and investigating their role in litter performance.Journal of animal science · 2026Article
- Liquid chromatography-mass spectrometry approach for characterizing sucrose isomers in complex mono-floral honey.Analytical and bioanalytical chemistry · 2025Article
- Electron Transfer Higher-Energy Collisional Dissociation Can Distinguish Cobalt-Adducted Isomers of Human Milk Oligosaccharides.Analytical chemistry · 2025Article
- Unusual free trisaccharides in caprine colostrum discovered by logically derived sequence tandem mass spectrometry.Scientific reports · 2025Article
- Collision-Induced Dissociations of Linear Hexose and Disaccharides with Linear Hexose at the Reducing End.The journal of physical chemistry. A · 2024Article
- High Abundance of Unusual High MannoseACS omega · 2024Article
- Collision-Induced Dissociation of Fucose and Identification of Anomericity.The journal of physical chemistry. A · 2024Article
- Chromatograms and Mass Spectra of High-Mannose and PaucimannoseJournal of proteome research · 2024Article
- Article
- Identification of the High MannoseAnalytical chemistry · 2023Article
- Identification of human milk oligosaccharide positional isomers by combining IMS-CID-IMS and cryogenic IR spectroscopy.The Analyst · 2023Article
- Unusual free oligosaccharides in human bovine and caprine milk.Scientific reports · 2022Article
- Characterization and Analysis of Food-Sourced Carbohydrates.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Identifying Mixtures of Isomeric Human Milk Oligosaccharides by the Decomposition of IR Spectral Fingerprints.Analytical chemistry · 2021Article
- A Multidimensional Mass Spectrometry-Based Workflow forJournal of the American Society for Mass Spectrometry · 2021Article
- Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry.Communications chemistry · 2021Article
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5 authors.
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Abstract
Carbohydrates have various functions in biological systems. However, the structural analysis of carbohydrates remains challenging. Most of the commonly used methods involve derivatization of carbohydrates or can only identify part of the structure. Here, we report a de novo method for completely structural identification of underivatised oligosaccharides. This method, which can provide assignments of linkages, anomeric configurations, and branch locations, entails low-energy collision-induced dissociation (CID) of sodium ion adducts that enable the cleavage of selective chemical bonds, a logical procedure to identify structurally decisive fragment ions for subsequent CID, and the specially prepared disaccharide CID spectrum databases. This method was first applied to determine the structures of four underivatised glucose oligosaccharides. Then, high-performance liquid chromatography and a mass spectrometer with a built-in logical procedure were established to demonstrate the capability of the in situ CID spectrum measurement and structural determination of the oligosaccharides in chromatogram. This consolidation provides a simple, rapid, sensitive method for the structural determination of glucose oligosaccharides, and applications to oligosaccharides containing hexoses other than glucose can be made provided the corresponding disaccharide databases are available.
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