ArticleScientific reports2018
Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Radiation-Induced Neurodegeneration.Biomedicines · 2026Review
- Evaluating the Effectiveness of Geant4 Software in Measuring the Damage Caused by Ti48 Ion Radiation on Nerve Cells, in Comparison to the Biophysical Model and Empirical Data.Current radiopharmaceuticals · 2025Article
- Radiation-Induced Cognitive Decline: Challenges and Solutions.Cancer management and research · 2024Review
- Ionizing radiation alters functional neurotransmission inFrontiers in cellular neuroscience · 2023Article
- Nano-scale simulation of neuronal damage by galactic cosmic rays.Physics in medicine and biology · 2022Article
- Review
- Predicting Space Radiation Single Ion Exposure in Rodents: A Machine Learning Approach.Frontiers in systems neuroscience · 2021Article
- Machine Learning Models to Predict Cognitive Impairment of Rodents Subjected to Space Radiation.Frontiers in systems neuroscience · 2021Article
- Can a comparison of clinical and deep space irradiation scenarios shed light on the radiation response of the brain?The British journal of radiology · 2020Article
- Mitigation of helium irradiation-induced brain injury by microglia depletion.Journal of neuroinflammation · 2020Article
- Sex-Specific Cognitive Deficits Following Space Radiation Exposure.Frontiers in behavioral neuroscience · 2020Article
- Risks of cognitive detriments after low dose heavy ion and proton exposures.International journal of radiation biology · 2019Review
- DETRIMENTS IN NEURON MORPHOLOGY FOLLOWING HEAVY ION IRRADIATION: WHAT'S THE TARGET?Radiation protection dosimetry · 2019Review
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and memory. The purpose of this study is to develop a novel predictive model of neuronal dendritic damages caused by exposure to low linear energy transfer (LET) radiation, such as X-rays, γ-rays and high-energy protons. We established in silico representations of mouse hippocampal dentate granule cell layer (GCL) and CA1 pyramidal neurons, which are frequently examined in radiation-induced cognitive decrements. The in silico representations are used in a stochastic model that describes time dependent dendritic damage induced by exposure to low LET radiation. Changes in morphometric parameters, such as total dendritic length, number of branch points and branch number, including the Sholl analysis for single neurons are described by the model. Our model based predictions for different patterns of morphological changes based on energy deposition in dendritic segments (EDDS) will serve as a useful basis to compare specific patterns of morphological alterations caused by EDDS mechanisms.
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Registered trials
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