ArticleScientific reports2018
Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Bibliometric analysis of human microbiota-associated animal model (2005-2025).Frontiers in microbiology · 2026Pooled it
- Pooled it
- Gut bacteria and their metabolites may influence our decisions, intelligence, cognition, and consciousness.Gut microbes · 2026Review
- Maternal and infant gut microbiome.iMeta · 2026Review
- Human milk and infant formula influence lactobacilli metabolism in a species-specific manner.NPJ science of food · 2026Article
- Germ-free piglets display variable neuroinflammatory-like perturbations in prefrontal cortical microglia.bioRxiv : the preprint server for biology · 2026Article
- Human gut microbiota and brain evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identifying gut microbiota composition disparities in autistic individuals and their unaffected siblings: correlations with clinical characteristics.Translational psychiatry · 2025Article
- How the gut microbiome shapes learning and memory: A comprehensive review.IBRO neuroscience reports · 2025Review
- Dynamic Interactions between the Gut Microbiome, Health, and Metabolic Disorders in Preterm Infants.Journal of microbiology and biotechnology · 2025Review
- Codevelopment of gut microbial metabolism and visual neural circuitry over human infancy.mBio · 2025Article
- Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders.Translational psychiatry · 2025Review
- The association between urinary antibiotics levels and the risk of adolescent depression.Scientific reports · 2025Article
- The endocannabinoidome-gut microbiome-brain axis as a novel therapeutic target for autism spectrum disorder.Journal of biomedical science · 2025Review
- Article
- Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review.Frontiers in neuroscience · 2025Review
- Article
- Exploring the microbiota-gut-brain axis: impact on brain structure and function.Frontiers in neuroanatomy · 2025Review
- Article
- The neonatal gut microbiota: A role in the encephalopathy of prematurity.Cell reports. Medicine · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Poor growth in the Neonatal Intensive Care Unit is associated with an increased risk for poor neurodevelopmental outcomes for preterm infants, however the mechanism is unclear. The microbiome has increasingly been recognized as a modifiable environmental factor to influence host development. Here we explore the hypothesis that the microbiome influences both growth phenotype and brain development. A germ free mouse transfaunation model was used to examine the effects of preterm infant microbiotas known to induce either high growth or low growth phenotypes on postnatal brain development. The microbiome which induced the low growth phenotype was associated with decreases in the neuronal markers NeuN and neurofilament-L as well as the myelination marker MBP when compared to the microbiome associated with the high growth phenotype. Additionally, poor growth phenotype-associated microbiota was associated with increased neuroinflammation marked by increased Nos1, as well as alteration in IGF-1 pathway including decreased circulating and brain IGF-1, decreased circulating IGFBP3, and increased Igfbp3 brain mRNA expression. This study suggests that growth-associated microbiota can influence early neuron and oligodendrocyte development and that this effect may be mediated by effects on neuroinflammation and circulating IGF-1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.