ArticleScientific reports2018
Importance of Serum Amino Acid Profile for Induction of Hepatic Steatosis under Protein Malnutrition.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Sex Differences in Hepatic VLDLR Response to Protein Restriction and Its Relationship with Hepatic Lipid Accumulation.Nutrients · 2026Article
- Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Remote regulation of hepatic lipid secretion in the intestine by metabolic interaction of dietary arginine with ornithine.Scientific reports · 2026Article
- Article
- Insulin Receptor Substrate-2 Regulates the Secretion of Growth Factors in Response to Amino Acid Deprivation.International journal of molecular sciences · 2025Article
- Liver Histomorphological Changes in First- and Second-Generation Rat Offspring Associated With Maternal Undernutrition.Canadian journal of gastroenterology & hepatology · 2025Article
- Longitudinal Evaluation of Developmental Protein Malnutrition Resembling Marasmic-Kwashiorkor Condition in Wistar Rats.Turkish journal of pharmaceutical sciences · 2024Article
- Metabolic Effects of Short-Term High-Fat Intake Vary Depending on Dietary Amino Acid Composition.Current developments in nutrition · 2024Article
- Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age.GeroScience · 2023Article
- Article
- Cardiometabolic Effects of Postnatal High-Fat Diet Consumption in Offspring Exposed to Maternal Protein RestrictionFrontiers in physiology · 2022Review
- Acylcarnitines: Can They Be Biomarkers of Diabetic Nephropathy?Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Rapid manipulation of mitochondrial morphology in a living cell with iCMM.Cell reports methods · 2021Article
- Article
- Assessment of the amino acid profile in Thai patients with type 2 diabetes mellitus using liquid chromatography-mass spectrometry.International health · 2021Article
- Metabolomic changes in severe acute malnutrition suggest hepatic oxidative stress: a secondary analysis.Nutrition research (New York, N.Y.) · 2021Article
- Very low-density lipoprotein receptor increases in a liver-specific manner due to protein deficiency but does not affect fatty liver in mice.Scientific reports · 2021Article
- Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent.Trends in pharmacological sciences · 2021Review
- Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats.Scientific reports · 2020Article
- Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota.The Journal of nutritional biochemistry · 2020Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported that a low-protein diet caused animals to develop fatty liver containing a high level of triglycerides (TG), similar to the human nutritional disorder "kwashiorkor". To investigate the underlying mechanisms, we cultured hepatocytes in amino acid-sufficient or deficient medium. Surprisingly, the intracellular TG level was increased by amino acid deficiency without addition of any lipids or hormones, accompanied by enhanced lipid synthesis, indicating that hepatocytes themselves monitored the extracellular amino acid concentrations to induce lipid accumulation in a cell-autonomous manner. We then confirmed that a low-amino acid diet also resulted in the development of fatty liver, and supplementation of the low-amino acid diet with glutamic acid to compensate the loss of nitrogen source did not completely suppress the hepatic TG accumulation. Only a dietary arginine or threonine deficiency was sufficient to induce hepatic TG accumulation. However, supplementation of a low-amino acid diet with arginine or threonine failed to reverse it. In silico analysis succeeded in predicting liver TG level from the serum amino acid profile. Based on these results, we conclude that dietary amino acid composition dynamically affects the serum amino acid profile, which is sensed by hepatocytes and lipid synthesis was activated cell-autonomously, leading to hepatic steatosis.
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