ArticleScientific reports2018
Renal Prognosis and Related Risk Factors for Henoch-Schönlein Purpura Nephritis: A Chinese Adult Patient Cohort.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Evidence-based guidelines for the diagnosis and management of adult-onset IgA vasculitis.Nature reviews. Rheumatology · 2026Guideline
- Clinical Efficacy of Chinese Medicine in Treating Adult Henoch-Schönlein Purpura: A Meta-Analysis.BioMed research international · 2026Pooled it
- Risk prediction models for renal injury in children with IgA vasculitis: a systematic review and meta-analysis.Pediatric rheumatology online journal · 2025Pooled it
- Clinical characteristics and renal risk stratification of mixed-type IgA vasculitis: a large-volume study.Frontiers in immunology · 2026Article
- An individualized prognostic nomogram integrating clinical and pathological features in pediatric IgA vasculitis nephritis.Frontiers in medicine · 2026Article
- Identification of risk factors for renal progression in adults with IgAV: a retrospective cohort study of a single center in northwest China.International urology and nephrology · 2025Article
- A case-based review of IgA vasculitis complicated with gastrointestinal infections: insights from a norovirus-associated case in an adolescent.Rheumatology international · 2025Review
- Disease Course and Long-Term Outcomes in Adult IgA Vasculitis Nephritis: A Prospective Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Case Report: Atypical anti-GBM nephritis coexisting with Henoch-Schönlein purpura nephritis: exploring the pathogenic nexus.Frontiers in immunology · 2025Article
- Worldwide Distribution and Extracutaneous Manifestations of Henoch-Schönlein Purpura in Adults: Narrative Review.JMIR dermatology · 2024Review
- Short-term outcome of patients with adult IgA vasculitis: a single-center experience.Frontiers in medicine · 2023Article
- Henoch-Schönlein Purpura in an Obese Adult with Elevated Transaminase: A Case Report and Literature Review.Ethiopian journal of health sciences · 2022Review
- Clinico-Epidemiological Profile and Outcome of Children with IgA Vasculitis in Aseer Region, Southwestern Saudi Arabia.Healthcare (Basel, Switzerland) · 2021Article
- Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.BMJ case reports · 2021Article
- IgA Vasculitis and IgA Nephropathy: Same Disease?Journal of clinical medicine · 2021Review
- MEST-C pathological score and long-term outcomes of child and adult patients with Henoch-Schönlein purpura nephritis.BMC nephrology · 2020Article
- iTRAQ quantitative proteomic analysis differentially expressed proteins and signal pathways in henoch-schönlein purpura nephritis.American journal of translational research · 2020Article
- Article
- Crescent lesions are not a predictive factor in adult-onset Henoch-Schönlein purpura nephritis.Clinical and experimental medicine · 2019Article
- Childhood IgA Vasculitis (Henoch Schonlein Purpura)-Advances and Knowledge Gaps.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the clinicopathological characteristics of Henoch-Schönlein purpura nephritis (HSPN) in Chinese adult patients and analyzed the renal outcomes and prognostic risk factors for progression to end-stage renal disease (ESRD). Adult patients who had biopsy-proven HSPN were studied. Their clinicopathological data, renal prognoses and related risk factors were assessed. A total of 698 patients were studied, including 363 men (52.0%) and 335 women (48.0%). Most of the patients had hematuria (85.8%) and/or proteinuria (82.1%). During a median follow-up of 54.0 months, 32 patients (4.6%) progressed to ESRD. The 5- and 10-year cumulative renal survival rates from ESRD were 96.4% and 88.6%, respectively. Baseline urinary protein, renal insufficiency, glomerular sclerosis and tubular atrophy/interstitial fibrosis were independent predictors of renal outcomes. Both the time-average mean arterial pressure and proteinuria during follow-up also influenced the renal prognosis. The patients with a time-average proteinuria <0.4 g/day had the lowest rates of ESRD or a 50% decline in renal function. In conclusion, identifying of clinical and histological prognostic factors may permit the prediction of renal outcomes. The optimal goal of therapy for HSPN patients may be to lower proteinuria to <0.4 g/day and control hypertension to achieve an ideal renal outcome.
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