ArticleNature communications2018
Pharmacologically induced amnesia for learned fear is time and sleep dependent.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Re-encountering the phobic cue within days after a reconsolidation intervention is crucial to observe a lasting fear reduction in spider phobia.Molecular psychiatry · 2025Trial
- Propranolol Administration During Morphine Addiction Attenuates Reinstatement of Drug-Aversive Memories Caused by Exposure to Stressful Stimuli.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales.eLife · 2025Article
- A brief treatment for veterans with PTSD: an open-label case-series study.Frontiers in psychiatry · 2023Article
- Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder.International journal of molecular sciences · 2022Review
- Over the Edge: Extending the duration of a reconsolidation intervention for spider fear.Translational psychiatry · 2022Article
- Sleep enhances reconsolidation-based strengthening of visuospatial memories.Scientific reports · 2022Article
- Better, worse, or different than expected: on the role of value and identity prediction errors in fear memory reactivation.Scientific reports · 2022Article
- Demarcating the boundary conditions of memory reconsolidation: An unsuccessful replication.Scientific reports · 2022Article
- Continuous theta-burst stimulation over the right dorsolateral prefrontal cortex disrupts fear memory reconsolidation in humans.iScience · 2022Article
- Interfering With Contextual Fear Memories by Post-reactivation Administration of Propranolol in Mice: A Series of Null Findings.Frontiers in behavioral neuroscience · 2022Article
- Perioperative Propranolol Against Dental Anxiety: A Randomized Controlled Trial.Frontiers in psychiatry · 2022Article
- Episodic memory enhancement versus impairment is determined by contextual similarity across events.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Suppressing the Morning Cortisol Rise After Memory Reactivation at 4 A.M. enhances Episodic Memory Reconsolidation in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Active suppression prevents the return of threat memory in humans.Communications biology · 2021Article
- Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia.Frontiers in psychiatry · 2021Article
- Propranolol-induced inhibition of unconditioned stimulus-reactivated fear memory prevents the return of fear in humans.Translational psychiatry · 2020Article
- The role of sleep in fear learning and memory.Current opinion in psychology · 2020Review
- Article
- Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans.Science advances · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery in animal research that fear memories may change upon retrieval has sparked a wave of interest into whether this phenomenon of reconsolidation also occurs in humans. The critical conditions under which memory reconsolidation can be observed and targeted in humans, however, remain elusive. Here we report that blocking beta-adrenergic receptors in the brain, either before or after reactivation, effectively neutralizes the expression of fear memory. We show a specific time-window during which beta-adrenergic receptors are involved in the reconsolidation of fear memory. Finally, we observe intact fear memory expression 12 h after reactivation and amnesic drug intake when the retention test takes place during the same day as the intervention, but post-reactivation amnesia after a night of sleep (12 h or 24 h later). We conclude that memory reconsolidation is not simply time-dependent, but that sleep is a final and necessary link to fundamentally change the fear memory engram.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.