ReviewJournal of developmental biology2017
Moving the Shh Source over Time: What Impact on Neural Cell Diversification in the Developing Spinal Cord?
Review in Journal of developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Molecular signatures of cell diversity modulated by long noncoding RNAs in the human fetal spinal cord.iScience · 2026Article
- Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish.G3 (Bethesda, Md.) · 2026Article
- Gsx2 regulates oligodendrocyte precursor formation in the zebrafish spinal cord.Developmental biology · 2026Article
- Gsx2 Regulates Oligodendrocyte Precursor Formation in the Zebrafish Spinal Cord.bioRxiv : the preprint server for biology · 2025Article
- Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Spinal Cord Injury Remyelination: Pathways to Therapies.International journal of molecular sciences · 2025Review
- Dynamics of morphogen source formation in a growing tissue.PLoS computational biology · 2024Article
- In Vivo Monitoring ofCells · 2024Article
- Lateral Motor Column specific expression of Sonic Hedgehog contributes to maintenance and scaling of pMN progenitor cell populations during oligodendrogenesis.Research square · 2024Article
- Mirk/Dyrk1B controls ventral spinal cord development via Shh pathway.Cellular and molecular life sciences : CMLS · 2024Article
- Reciprocal Regulation of Shh Trafficking and HAntioxidants (Basel, Switzerland) · 2022Article
- Sonic Hedgehog Signaling in Cerebellar Development and Cancer.Frontiers in cell and developmental biology · 2022Review
- Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations.Developmental biology · 2021Article
- Article
- Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord.Scientific reports · 2021Article
- Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating the Shh signaling response.Development (Cambridge, England) · 2020Article
- yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development.PLoS genetics · 2020Article
- Neural tube development depends on notochord-derived sonic hedgehog released into the sclerotome.Development (Cambridge, England) · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A substantial amount of data has highlighted the crucial influence of Shh signalling on the generation of diverse classes of neurons and glial cells throughout the developing central nervous system. A critical step leading to this diversity is the establishment of distinct neural progenitor cell domains during the process of pattern formation. The forming spinal cord, in particular, has served as an excellent model to unravel how progenitor cells respond to Shh to produce the appropriate pattern. In recent years, considerable advances have been made in our understanding of important parameters that control the temporal and spatial interpretation of the morphogen signal at the level of Shh-receiving progenitor cells. Although less studied, the identity and position of Shh source cells also undergo significant changes over time, raising the question of how moving the Shh source contributes to cell diversification in response to the morphogen. Here, we focus on the dynamics of Shh-producing cells and discuss specific roles for these time-variant Shh sources with regard to the temporal events occurring in the receiving field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.