Evidence map›Paper›PMID 29615501›Full record

ArticlemBio2018

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis.

Gregory C Kujoth, Thomas D Sullivan, Richard Merkhofer, Taek-Jin Lee, Huafeng Wang, Tristan Brandhorst, Marcel Wüthrich, Bruce S Klein

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Tools for genetic manipulation of the endemic fungal pathogen,bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Utilization of amSphere · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. mBio · 2023
    Article
  11. Article
  12. Unique Attributes of the Laurel Wilt Fungal Pathogen,Pathogens (Basel, Switzerland) · 2021
    Article
  13. Updates inJournal of fungi (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Review
  16. Gene Editing in Dimorphic Fungi Using CRISPR/Cas9.Current protocols in microbiology · 2020
    Article
  17. Zinc at the Host-Fungus Interface: How to Uptake the Metal?Journal of fungi (Basel, Switzerland) · 2020
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gregory C KujothDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Thomas D SullivanDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Richard MerkhoferDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Taek-Jin LeeDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Huafeng WangDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tristan BrandhorstDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Marcel WüthrichDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Bruce S KleinDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA bsklein@pediatrics.wisc.edu.
University of Wisconsin–Madison · US

Funding

PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Molecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Regulation of vaccine-induced anti-fungal Th17 cellsR01AI093553 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WUETHRICH, MARCEL · 2011 to 2020
$4.5M
MOLECULAR PATHOGENESIS OF BLASTOMYCOSISR01AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 1995 to 2019
$3.9M
Lung epithelial cell regulation of immunity to inhaled fungiR01AI130411 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2018 to 2021
$2.0M
Hybrid histidine kinase: a drug target and path to anti-fungal drug developmentR21AI123758 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2017 to 2018
$408k
Pathogenesis of fungal infectious disease in the Hmong populationF30MD011547 · NIMHD · UNIVERSITY OF WISCONSIN-MADISON · PI MERKHOFER, RICHARD MICHAEL · 2017 to 2020
$157k
NIAID NIH HHS R01 AI035681NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI093553NIAID NIH HHS R01 AI130411NIAID NIH HHS R21 AI123758NIAID NIH HHS R37 AI035681NIAID NIH HHS T32 AI055397NIGMS NIH HHS T32 GM008692NIMHD NIH HHS F30 MD011547
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic FitnessAnimalsBlastomycesBlastomycosisClustered Regularly Interspaced Short Palindromic RepeatsColony Count, MicrobialCRISPR-Associated Protein 9Disease Models, AnimalGene EditingMetabolic Networks and PathwaysMiceRNA, Guide, CRISPR-Cas SystemsZincCRISPR-Associated Protein 9RNA, Guide, CRISPR-Cas SystemsZincCRISPRfungigeneticspathogenesisvirulence

Identifiers

PMID29615501
PMCPMC5885028
OpenAlexW2795376785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.