Evidence map›Paper›PMID 29615499›Full record

ArticlemBio2018

EF-P Posttranslational Modification Has Variable Impact on Polyproline Translation in

Anne Witzky, Katherine R Hummels, Rodney Tollerson, Andrei Rajkovic, Lisa A Jones, Daniel B Kearns, Michael Ibba

Abstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Translation factors that keep the ribosome Pro-active.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. YfmR is a translation factor that prevents ribosome stalling and cell death in the absence of EF-P.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Translation elongation factor P (EF-P).FEMS microbiology reviews · 2020
    Review
  19. Review
  20. Complex Structure ofJournal of bacteriology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anne WitzkyDepartment of Molecular Genetics, Ohio State University, Columbus, Ohio, USA.
Katherine R HummelsDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Rodney TollersonDepartment of Microbiology, Ohio State University, Columbus, Ohio, USA.
Andrei RajkovicCenter for RNA Biology, Ohio State University, Columbus, Ohio, USA.
Lisa A JonesProteomics Facility, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Daniel B KearnsDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Michael IbbaCenter for RNA Biology, Ohio State University, Columbus, Ohio, USA ibba.1@osu.edu.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Mechanisms of translational controlR01GM065183 · NIGMS · OHIO STATE UNIVERSITY · PI DUNHAM, CHRISTINE M, FREDRICK, KURT L · 2003 to 2020
$4.9M
The mechanism of bistable motility gene expression in Bacillus subtilis.R01GM093030 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI KEARNS, DANIEL B · 2010 to 2018
$2.6M
Cellular, molecular, and biochemical sciences training grantT32GM086252 · NIGMS · OHIO STATE UNIVERSITY · PI JACKMAN, JANE ELIZABETH, MUSIER-FORSYTH, KARIN M · 2011 to 2020
$2.0M
A Systems Biology Approach for Targeted Drug Discovery for LeishmaniasisR21AI127582 · NIAID · OHIO STATE UNIVERSITY · PI IBBA, MICHAEL, SATOSKAR, ABHAY R · 2017 to 2018
$401k
NCI NIH HHS P30 CA015704NIAID NIH HHS R21 AI127582NIGMS NIH HHS R01 GM065183NIGMS NIH HHS R01 GM093030NIGMS NIH HHS T32 GM086252
6 · The paper itself

Abstract

Elongation factor P (EF-P) is a ubiquitous translation factor that facilitates translation of polyproline motifs. In order to perform this function, EF-P generally requires posttranslational modification (PTM) on a conserved residue. Although the position of the modification is highly conserved, the structure can vary widely between organisms. In

Indexed as

Protein BiosynthesisProtein Processing, Post-TranslationalBacillus subtilisGenes, BacterialLysineMetabolic Networks and PathwaysPeptide Elongation FactorsPeptidesfactor EF-PLysinePeptide Elongation FactorsPeptidespolyprolineelongationposttranslational modificationprotein synthesistranslational

Identifiers

PMID29615499
PMCPMC5885033

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.