Evidence map›Paper›PMID 29615494›Full record

ArticleThe Journal of biological chemistry2018

Small molecules that inhibit the late stage of Munc13-4-dependent secretory granule exocytosis in mast cells.

Stephen Bruinsma, Declan J James, Melanie Quintana Serrano, Joseph Esquibel, Sang Su Woo, Elle Kielar-Grevstad, Ellen Crummy, Rehan Qurashi, Judy A Kowalchyk, Thomas F J Martin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. InhibitingBiomedicines · 2025
    Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Stephen BruinsmaDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Declan J JamesDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Melanie Quintana SerranoDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Joseph EsquibelDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Sang Su WooDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Elle Kielar-GrevstadDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Ellen CrummyDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Rehan QurashiDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Judy A KowalchykDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706.
Thomas F J MartinDepartment of Biochemistry, University of Wisconsin, Madison Wisconsin 53706. Electronic address: tfmartin@wisc.edu.
University of Wisconsin–Madison · USUniversity of Wisconsin System · US

Funding

Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
THE MECHANISM OF ACTION OF THYROTROPIN-RELEASING HORMONER01DK025861 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MARTIN, THOMAS F. J. · 1986 to 2024
$5.6M
SCREENING FOR INHIBITORS OF VESICLE EXOCYTOSISR21NS064833 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI MARTIN, THOMAS F. J. · 2009 to 2009
$141k
NIDDK NIH HHS R01 DK025861NIGMS NIH HHS T32 GM008688NINDS NIH HHS R21 NS064833
6 · The paper itself

Abstract

Ca

Indexed as

ExocytosisAnimalsCell DegranulationLeukemia, Basophilic, AcuteMast CellsMembrane FusionProteinsRatsSecretory VesiclesSmall Molecule LibrariesTumor Cells, CulturedProteinsSmall Molecule LibrariesUnc13d protein, ratexocytosisinhibitorintracellular traffickingmast cellmembrane fusionMunc13-4secretionsmall molecule

Identifiers

PMID29615494
PMCPMC5971468
OpenAlexW2795769232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.