Evidence map›Paper›PMID 29615482›Full record

ArticleRNA (New York, N.Y.)2018

Defining essential elements and genetic interactions of the yeast Lsm2-8 ring and demonstration that essentiality of Lsm2-8 is bypassed via overexpression of U6 snRNA or the U6 snRNP subunit Prp24.

Allen J Roth, Stewart Shuman, Beate Schwer

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Allen J RothMicrobiology and Immunology Department, Weill Cornell Medical College, New York, New York 10065, USA.
Stewart ShumanMolecular Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
Beate SchwerMicrobiology and Immunology Department, Weill Cornell Medical College, New York, New York 10065, USA.
Cornell University · USKettering University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
mRNA Capping EnzymesR01GM052470 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SCHWER, BEATE, SHUMAN, STEWART H · 1995 to 2019
$9.9M
RNA caps and meiotic pre-mRNA splicingR01GM102961 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWER, BEATE · 2013 to 2016
$1.3M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM052470NIGMS NIH HHS R01 GM102961
6 · The paper itself

Abstract

A seven-subunit Lsm2-8 protein ring assembles on the U-rich 3' end of the U6 snRNA. A structure-guided mutational analysis of the

Indexed as

Amino Acid SequenceBinding SitesMutationProtein BindingRibonucleoproteins, Small NuclearRNA, FungalRNA, Small NuclearRNA SplicingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence DeletionLsm2 protein, S cerevisiaePrp24 protein, S cerevisiaeRibonucleoproteins, Small NuclearRNA, FungalRNA, Small NuclearSaccharomyces cerevisiae ProteinsU6 small nuclear RNALsm proteinsmRNA splicingPrp24U6 snRNA

Identifiers

PMID29615482
PMCPMC5959253
OpenAlexW2796257351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.