Evidence map›Paper›PMID 29615467›Full record

ArticleDevelopment (Cambridge, England)2018

Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner.

Enrico Cristante, Sidath E Liyanage, Robert D Sampson, Aikaterini Kalargyrou, Giulia De Rossi, Matteo Rizzi, Justin Hoke, Joana Ribeiro, Ryea N Maswood, Yanai Duran and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Neurovascular abnormalities in retinopathy of prematurity and emerging therapies.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
  4. Article
  5. Article
  6. Adaptation of the Oxygen Sensing System during Lung Development.Oxidative medicine and cellular longevity · 2022
    Article
  7. Article
  8. Review
  9. Roles of HIFs and VEGF in angiogenesis in the retina and brain.The Journal of clinical investigation · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Enrico CristanteUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK e.cristante@ucl.ac.uk j.bainbridge@ucl.ac.uk.ORCID 0000-0002-5454-1553
Sidath E LiyanageUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Robert D SampsonUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Aikaterini KalargyrouUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Giulia De RossiCentre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Matteo RizziUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Justin HokeUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Joana RibeiroUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Ryea N MaswoodUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Yanai DuranUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Takaaki MatsukiUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Nozie D AghaizuUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Ulrich F LuhmannUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Alexander J SmithUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Robin R AliUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
James W B BainbridgeUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK e.cristante@ucl.ac.uk j.bainbridge@ucl.ac.uk.ORCID 0000-0003-1318-8201
University College London · GBMoorfields Eye Hospital NHS Foundation Trust · GBQueen Mary University of London · GB

Funding

Department of Health NIHR-RP-011-003Medical Research Council MR/K003003/1
6 · The paper itself

Abstract

In the adult central nervous system, endothelial and neuronal cells engage in tight cross-talk as key components of the so-called neurovascular unit. Impairment of this important relationship adversely affects tissue homeostasis, as observed in neurodegenerative conditions including Alzheimer's and Parkinson's disease. In development, the influence of neuroprogenitor cells on angiogenesis is poorly understood. Here, we show in mouse that these cells interact intimately with the growing retinal vascular network, and we identify a novel regulatory mechanism of vasculature development mediated by hypoxia-inducible factor 2a (Hif2a). By

Indexed as

AnimalsAstrocytesBasic Helix-Loop-Helix ProteinsCell ProliferationEndostatinsEndothelial PAS Domain-Containing Protein 1Gene Expression Regulation, DevelopmentalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeovascularization, PhysiologicNeural Stem CellsRetinal Ganglion CellsRetinal Pigment EpitheliumRetinal VesselsBasic Helix-Loop-Helix ProteinsEndostatinsEndothelial PAS Domain-Containing Protein 1Kdr protein, mouseVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVascular Endothelial Growth Factor Receptor-2AngiogenesisCre/loxEndostatinEpas1Hif2aNeuroprogenitorRetina

Identifiers

PMID29615467
PMCPMC5964651
OpenAlexW2795471405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.