Evidence map›Paper›PMID 29615452›Full record

ArticleThe EMBO journal2018

Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.

Bettina Reichenbach, Johanna Classon, Tomomi Aida, Kohichi Tanaka, Maria Genander, Christian Göritz

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

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  9. Ontogeny of Skin Stem Cells and Molecular Underpinnings.Current issues in molecular biology · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bettina ReichenbachDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Johanna ClassonDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Tomomi AidaLaboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Kohichi TanakaLaboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Maria GenanderDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Christian GöritzDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden christian.goeritz@ki.se.ORCID 0000-0003-0799-766X
Karolinska Institutet · SETokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissues contain distinct stem cell niches, but whether cell turnover is coordinated between niches during growth is unknown. Here, we report that in mouse skin, hair growth is accompanied by sebaceous gland and interfollicular epidermis expansion. During hair growth, cells in the bulge and outer root sheath temporarily upregulate the glutamate transporter SLC1A3, and the number of SLC1A3

Indexed as

AnimalsCell ProliferationEpidermisExcitatory Amino Acid Transporter 1Gene Expression RegulationMiceMice, TransgenicSebaceous GlandsStem CellsExcitatory Amino Acid Transporter 1Slc1a3 protein, mouseepithelial stem cellsglutamate signalingskinSlc1a3stem cell activation

Identifiers

PMID29615452
PMCPMC5920238
OpenAlexW2796335919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.