Evidence map›Paper›PMID 29615104›Full record

ArticleBMC research notes2018

Genetic analysis for rs2280205 (A>G) and rs2276961 (T>C) in SLC2A9 polymorphism for the susceptibility of gout in Cameroonians: a pilot study.

Jan René Nkeck, Madeleine Singwé Ngandeu, Vicky Ama Moor, Jériel Pascal Nkeck, Jean-Pierre Chedjou, Aude Laetitia Ndoadoumgue, Wilfred F Mbacham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jan René NkeckFaculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon. jrnkeck@gmail.com.
Madeleine Singwé NgandeuFaculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.
Vicky Ama MoorFaculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.
Jériel Pascal NkeckFaculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.
Jean-Pierre ChedjouLaboratory of Public Health Biotechnology, Biotechnology Centre of the University of Yaoundé I, Yaoundé, Cameroon.
Aude Laetitia NdoadoumgueSchool of Health and Related Research, The University of Sheffield, Sheffield, UK.
Wilfred F MbachamFaculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.
Université de Yaoundé I · CMUniversity of Sheffield · GBUniversity Teaching Hospital of Yaounde · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the association of non-synonymous variants rs2280205 and rs2276961 of the SLC2A9 gene to gout in Cameroonians.

resultsIn a case-control study including 30 patients with acute gout matched to 30 healthy volunteers. We searched for polymorphism of the targeted variants using Restriction Fragment Length Polymorphism following polymerize chain reaction. Fisher exact test and Student t-test were used to compare variables, with a threshold of significance set at 0.05. The mean age of participants was 58 ± 8 years with 28 (93%) males. The family history of gout was found in one-third of the cases (p > 0.05). Uricemia was higher in cases than controls (p < 0.001) but 24 h urate excretion was similar in both groups (p > 0.05). Ancestral alleles (G and C) and their homozygous genotypes (GG and CC) of the targeted variants were predominant in both groups (p < 0.001). The polymorphisms of targeted variants were not associated with gout, and do not influence uric acid concentration in blood and urine. Non-synonymous variants rs2280205 and rs2276961 are not associated with gout in Cameroonians. However, the hereditary component of the disease suggests the influence of other genetic and/or environmental factors.

Indexed as

AgedCameroonCase-Control StudiesFemaleGenetic Predisposition to DiseaseGlucose Transport Proteins, FacilitativeGoutHumansMaleMiddle AgedPilot ProjectsPolymerase Chain ReactionPolymorphism, Single NucleotideGlucose Transport Proteins, FacilitativeSLC2A9 protein, humanGeneticGoutNon-synonymous variantsrs2276961rs2280205SLC2A9

Identifiers

PMID29615104
PMCPMC5883404
OpenAlexW2806002993

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