ArticleBMC veterinary research2018
First molecular detection and characterization of Marek's disease virus in red-crowned cranes (Grus japonensis): a case report.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 19 citations in OpenAlex.
- An Overview of Avian Vaccination Options in Zoological Collections in Europe.Veterinary sciences · 2026Review
- Birds of a feather flock together: structural characterization of red-crowned crane and turkey aveparvoviruses.Journal of virology · 2025Article
- Diversity of Marek's Disease Virus Strains in Infections in Backyard and Ornamental Birds.Animals : an open access journal from MDPI · 2024Article
- Article
- Identification of Multiple Novel Viruses in Fecal Samples of Black-Necked Cranes Using Viral Metagenomic Methods.Viruses · 2023Article
- Isolation and characterization of a novel parvovirus from a red-crowned crane, China, 2021.BMC veterinary research · 2023Article
- A Review on the Marek's Disease Outbreak and Its Virulence-RelatedAnimals : an open access journal from MDPI · 2022Review
- Natural outbreak of Marek's disease in indigenous chicken and Japanese quail (Open veterinary journal · 2019Article
- The fecal virome of red-crowned cranes.Archives of virology · 2019Article
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9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMarek's disease virus (MDV) resides in the genus Mardivirus in the family Herpesviridae. MDV is a highly contagious virus that can cause neurological lesions, lymphocytic proliferation, immune suppression, and death in avian species, including Galliformes (chickens, quails, partridges, and pheasants), Strigiformes (owls), Anseriformes (ducks, geese, and swans), and Falconiformes (kestrels). CASE PRESENTATION: In 2015, two red-crowned cranes died in Nanjing (Jiangsu, China). It was determined that the birds were infected with Marek's disease virus by histopathological examination, polymerase chain reaction (PCR), gene sequencing and sequence analysis of tissue samples from two cranes. Gross lesions included diffuse nodules in the skin, muscle, liver, spleen, kidney, gizzard and heart, along with liver enlargement and gizzard mucosa hemorrhage. Histopathological assay showed that infiltrative lymphocytes and mitotic figures existed in liver and heart. The presence of MDV was confirmed by PCR. The sequence analysis of the Meq gene showed 100% identity with Md5, while the VP22 gene showed the highest homology with CVI988. Furthermore, the phylogenetic analysis of the VP22 and Meq genes suggested that the MDV (from cranes) belongs to MDV serotype 1.
conclusionWe describe the first molecular detection of Marek's disease in red-crowned cranes based on the findings previously described. To our knowledge, this is also the first molecular identification of Marek's disease virus in the order Gruiformes and represents detection of a novel MDV strain.
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