Evidence map›Paper›PMID 29614989›Full record

ArticleBMC pediatrics2018

Using the ages and stages questionnaire in the general population as a measure for identifying children not at risk of a neurodevelopmental disorder.

Ramesh Lamsal, Daniel J Dutton, Jennifer D Zwicker

Abstract readValidation Study
In one paragraph

Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ramesh LamsalSchool of Public Policy, University of Calgary, 906 8th Ave SW, Calgary, Canada.
Daniel J DuttonSchool of Public Policy, University of Calgary, 906 8th Ave SW, Calgary, Canada.
Jennifer D ZwickerSchool of Public Policy, University of Calgary, 906 8th Ave SW, Calgary, Canada. zwicker1@ucalgary.ca.ORCID 0000-0002-0722-5929

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly detection of neurodevelopmental disorders (NDDs) enables access to early interventions for children. We assess the Ages and Stages Questionnaire (ASQ)'s ability to identify children with a NDD in population data.

methodChildren 4 to 5 years old in the National Longitudinal Survey of Children and Youth (NLSCY) from cycles 5 to 8 were included. The sensitivity, specificity, positive and negative predictive values were calculated for the ASQ at 24, 27, 30, 33, 36 and 42 months. Fixed effects regression analyses assessed longitudinal associations between domain scores and child age.

resultsSpecificity for the ASQ was high with 1SD or 2SD cutoffs, indicating good accuracy in detecting children who will not develop a NDD, however the sensitivity varied over time points and cut-offs. Sensitivity for the 1 SD cutoff at 24 months was above the recommended value of 70% for screening. Differences in ASQ domains scores between children with and without NDD increases with age.

conclusionsThe high specificity and negative predictive values of the ASQ support its use in identifying children who are not at the risk of developing a NDD. The capacity of the ASQ to identify children with a NDD in the general population is limited except for the ASQ-24 months with 1SD and can be used to identify children at risk of NDD.

Indexed as

Surveys and QuestionnairesAge FactorsChild, PreschoolDevelopmental DisabilitiesEarly DiagnosisFemaleHumansLongitudinal StudiesMaleParentsRisk FactorsSensitivity and SpecificityAges and stages questionnaire (ASQ)Early identificationEarly interventionNeurodevelopmental disabilitiesScreening

Identifiers

PMID29614989
PMCPMC5883588

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.