Evidence map›Paper›PMID 29614986›Full record

ArticleBMC pediatrics2018

Rapunzel syndrome: an infrequent cause of severe iron deficiency anemia and abdominal pain presenting to the pediatric emergency department.

Giuseppe Cannalire, Luigi Conti, Maurizio Celoni, Carmine Grassi, Andrea Cella, Giulia Bensi, Patrizio Capelli, Giacomo Biasucci

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Untangling rapunzel syndrome: A unique presentation of gastric trichobezoar.International journal of surgery case reports · 2025
    Article
  7. Gastroduodenal Obstruction Secondary to Pica-associated Bezoar: A Case Report.Clinical practice and cases in emergency medicine · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Giuseppe CannalireDepartment of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy. g.cannalire@ausl.pc.it.ORCID 0000-0003-0308-2825
Luigi ContiDepartment of General, Thoracic and Breast Surgery, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy.
Maurizio CeloniDepartment of General, Thoracic and Breast Surgery, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy.
Carmine GrassiDepartment of General, Thoracic and Breast Surgery, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy.
Andrea CellaDepartment of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy.
Giulia BensiDepartment of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy.
Patrizio CapelliDepartment of General, Thoracic and Breast Surgery, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy.
Giacomo BiasucciDepartment of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy.
Guglielmo da Saliceto Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIron deficiency anemia (IDA) and abdominal pain are commonly seen in a pediatric emergency department (8 and 18% incidence respectively in our center). They are manifestations of a wide variety of diseases ranging from benign to immediately life-threatening. Trichobezoar is an under-diagnosed entity that has to be considered in children and adolescents, expecially female, suffering from trichotillomania (compulsion to pull hair) and trichophagy (compulsion to swallow hair). When undiagnosed, gastric bezoars may cause gastric ulceration, perforation, haemorrhage and obstruction. CASE PRESENTATION: To underline the importance of including this pathology in the differential diagnosis of IDA and abdominal pain, we present the case of a 14 year-old girl with a huge trichobezoar which completely filled the stomach and extended into the small bowel. Since trichobezoar has an extension to the small bowel, it is classified as Rapunzel syndrome. As the bezoar couldn't be removed by endoscopy, the girl underwent surgical intervention. The patient passed through a gradual re-feeding, with iron and vitamins supplementation, and through a psychiatric counselling.

conclusionThe Rapunzel syndrome is a rare entity that may be complicated by life-threatening events. A prompt diagnosis and an appropriate therapy can reduce comorbidities. Gradual re-feeding with supplementation of micronutrients allows adequate catch-up weight with normalization of haematochemical nutritional parameters. Since many of these patients suffer from psychiatric pathology such as PICA with emotional problems and mental retardation, psychological/psychiatric counselling plays an important role in order to prevent bezoar recurrence.

Indexed as

Abdominal PainAdolescentAnemia, Iron-DeficiencyBezoarsDiagnosis, DifferentialDuodenumEmergency Service, HospitalFemaleHumansPicaStomachSyndromeTomography, X-Ray ComputedTrichotillomaniaUltrasonographyAbdominal painCase reportIron deficiency anemiaPICARapunzel syndromeTrichobezoarTrichophagiaTrichotillomania

Identifiers

PMID29614986
PMCPMC5883293
OpenAlexW2796027610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.