ArticleBMC geriatrics2018
Biological clocks and physical functioning in monozygotic female twins.
Article in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions.Biomedicines · 2023Article
- Aging-Related Multisystem Dysregulation Over the Adult Life Span and Physical Function in Later Life: The Atherosclerosis Risk in Communities (ARIC) Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock.Antioxidants (Basel, Switzerland) · 2022Review
- The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning.Clinical epigenetics · 2021Article
- Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity.Clinical epigenetics · 2021Article
- A Biological Age Model Designed for Health Promotion Interventions: Protocol for an Interdisciplinary Study for Model Development.JMIR research protocols · 2020Article
- One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project.GeroScience · 2020Article
- DNA Methylation Age and Physical and Cognitive Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Measuring biological aging in humans: A quest.Aging cell · 2020Review
- The role of DNA methylation in epigenetics of aging.Pharmacology & therapeutics · 2019Review
- Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans.Frontiers in physiology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiomarkers of biological aging - DNA methylation age (DNAm age) and leukocyte telomere length (LTL)- correlate strongly with chronological age across the life course. It is, however, unclear how these measures of cellular wear and tear are associated with muscle strength and functional capacity, which are known to decline with older age and are associated with mortality. We investigated if DNAm age and LTL were associated with body composition and physical functioning by examining 48 monozygotic twin sisters.
methodsWhite blood cell DNAm age (predicted years) was calculated from Illumina 450 k BeadChip methylation data using an online calculator. DNAm age acceleration was defined from the residuals derived from a linear regression model of DNAm age on chronological age. LTL was measured by qPCR. Total body percentage of fat and lean mass were estimated using bioimpedance. Physical functioning was measured by grip strength, knee extension strength and by 10 m maximal walking speed test.
resultsIn all participants, DNAm age (58.4 ± 6.6) was lower than chronological age (61.3 ± 5.9 years). Pairwise correlations of monozygotic co-twins were high for DNAm age (0.88, 95% CI 0.79, 0.97), age acceleration (0.68, 95% CI 0.30, 0.85) and LTL (0.77, 95% CI 0.60, 0.94). Increased age acceleration i.e. faster epigenetic aging compared to chronological age was associated with lower grip strength (β = - 5.3 SE 1.9 p = 0.011), but not with other measures of physical functioning or body composition. LTL was not associated with body composition or physical functioning.
conclusionsTo conclude, accelerated DNAm age is associated with lower grip strength, a biomarker known to be associated with physiological aging, and which predicts decline in physical functioning and mortality. Further studies may clarify whether epigenetic aging explains the decline in muscle strength with aging or whether DNAm age just illustrates the progress of aging.
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