ArticleBMC evolutionary biology2018
Phylogenomics and barcoding of Panax: toward the identification of ginseng species.
Article in BMC evolutionary biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Emerging Breakthroughs in Nano-Ginseng Innovations and Their Therapeutic Implications in Type 2 Diabetes.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Ginseng-Based Nanotherapeutics in Cancer Treatment: State-of-the-Art Progress, Tackling Gaps, and Translational Achievements.Current issues in molecular biology · 2025Review
- The multi-chromosomal structure of mitogenomes provided new insights into the accurate authentication of medicinal Dendrobium species.BMC plant biology · 2025Article
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- Deoxyribonucleic Acid Barcoding for the Identification of Botanicals.Progress in the chemistry of organic natural products · 2023Article
- Phylogenomics, plastome structure and species identification in Mahonia (Berberidaceae).BMC genomics · 2022Article
- Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation.Apoptosis : an international journal on programmed cell death · 2022Article
- Discrimination ofFrontiers in plant science · 2022Review
- Target Capture Reveals the Complex Origin of Vietnamese Ginseng.Frontiers in plant science · 2022Article
- Species discrimination of novel chloroplast DNA barcodes and their application for identification ofPhytoKeys · 2022Article
- Development of Hydrolysis Probe-Based qPCR Assays forFoods (Basel, Switzerland) · 2021Article
- DNA Metabarcoding for Quality Control of Basil, Oregano, and Paprika.Frontiers in plant science · 2021Article
- Complete Chloroplast Genome Analysis of Two Important MedicinalFrontiers in plant science · 2021Article
- Molecular dating for phylogenies containing a mix of populations and species by using Bayesian and RelTime approaches.Molecular ecology resources · 2021Article
- Engaging the next generation of plant geneticists through sustained research: an overview of a post-16 project.Heredity · 2020Review
- The large single-copy (LSC) region functions as a highly effective and efficient molecular marker for accurate authentication of medicinalActa pharmaceutica Sinica. B · 2020Article
- De novo assembly and Transcriptome characterization of an endemic species of Vietnam, Panax vietnamensis Ha et Grushv., including the development of EST-SSR markers for population genetics.BMC plant biology · 2020Article
- Complete plastome sequencing resolves taxonomic relationships among species of Calligonum L. (Polygonaceae) in China.BMC plant biology · 2020Article
- Microfluidic Enrichment Barcoding (MEBarcoding): a new method for high throughput plant DNA barcoding.Scientific reports · 2020Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe economic value of ginseng in the global medicinal plant trade is estimated to be in excess of US$2.1 billion. At the same time, the evolutionary placement of ginseng (Panax ginseng) and the complex evolutionary history of the genus is poorly understood despite several molecular phylogenetic studies. In this study, we use a full plastome phylogenomic framework to resolve relationships in Panax and to identify molecular markers for species discrimination.
resultsWe used high-throughput sequencing of MBD2-Fc fractionated Panax DNA to supplement publicly available plastid genomes to create a phylogeny based on fully assembled and annotated plastid genomes from 60 accessions of 8 species. The plastome phylogeny based on a 163 kbp matrix resolves the sister relationship of Panax ginseng with P. quinquefolius. The closely related species P. vietnamensis is supported as sister of P. japonicus. The plastome matrix also shows that the markers trnC-rps16, trnS-trnG, and trnE-trnM could be used for unambiguous molecular identification of all the represented species in the genus.
conclusionsMBD2 depletion reduces the cost of plastome sequencing, which makes it a cost-effective alternative to Sanger sequencing based DNA barcoding for molecular identification. The plastome phylogeny provides a robust framework that can be used to study the evolution of morphological characters and biosynthesis pathways of ginsengosides for phylogenetic bioprospecting. Molecular identification of ginseng species is essential for authenticating ginseng in international trade and it provides an incentive for manufacturers to create authentic products with verified ingredients.
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