ArticleJournal of Alzheimer's disease : JAD2018
Neuropsychiatric Symptoms and the Diagnostic Stability of Mild Cognitive Impairment.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies.Journal of geriatric psychiatry and neurology · 2023Pooled it
- Prevalence of Depression, Anxiety and PTSD in People with Dementia: a Systematic Review and Meta-Analysis.Neuropsychology review · 2018Pooled it
- Assessment of Music Experiences in Navigating Depression (AMEND) through a Tour of the Room assessment model.Frontiers in psychiatry · 2026Article
- Protective Potential ofCurrent issues in molecular biology · 2025Review
- Predictors of Bi-directional Transitions From Mild Cognitive Impairment in a Diverse Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Longitudinal Patterns and Predictors of Cognitive Impairment Classification Stability.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Tau PET positivity predicts clinically relevant cognitive decline driven by Alzheimer's disease compared to comorbid cases; proof of concept in the ADNI study.Molecular psychiatry · 2025Article
- Predictive value of nutritional status and serological indicators in elderly patients with mild cognitive impairment.World journal of psychiatry · 2024Article
- A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Platelets and Neurodegenerative Diseases: Current Knowledge and Future Perspectives.International journal of molecular sciences · 2024Review
- Mild behavioral impairment in early Alzheimer's disease and its association with APOE and BDNF risk genetic polymorphisms.Alzheimer's research & therapy · 2024Article
- Predictive variables of depressive symptoms and anxiety in older adults from primary care: a cross-sectional observational study.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024Observational
- Estimating Bidirectional Transitions and Identifying Predictors of Mild Cognitive Impairment.Neurology · 2023Article
- Aggressive behavior and prognosis in patients with mild cognitive impairment.Dementia & neuropsychologia · 2023Article
- Association between cognitive diagnosis and a range of significant life events in an elderly essential tremor cohort: a longitudinal, prospective analysis.Frontiers in neurology · 2023Article
- Plasma p-tauAlzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Progression to Dementia or Reversion to Normal Cognition in Mild Cognitive Impairment as a Function of Late-Onset Neuropsychiatric Symptoms.Neurology · 2022Article
- Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis.Scientific reports · 2021Article
- Biological Features of Reversion from Mild Cognitive Impairment to Normal Cognition: A Study of Cerebrospinal Fluid Markers and Brain Volume.Journal of Alzheimer's disease reports · 2021Article
- Neuropsychiatric Presentations due to Traumatic Brain Injury in Cognitively Normal Older Adults.Journal of neurotrauma · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMild cognitive impairment (MCI) is an intermediate diagnosis between normal cognition (NC) and dementia, including Alzheimer's disease (AD) dementia. However, MCI is heterogeneous; many individuals subsequently revert to NC while others remain stable at MCI for several years. Identifying factors associated with this diagnostic instability could assist in defining clinical populations and determining cognitive prognoses.
objectiveThe current study examined whether neuropsychiatric symptoms could partially account for the temporal instability in cognitive diagnoses.
methodThe sample included 6,763 participants from the National Alzheimer's Coordinating Center Uniform Data Set. All participants had NC at baseline, completed at least two follow-up visits (mean duration: 5.5 years), and had no recent neurological conditions. Generalized linear models estimated by generalized estimating equations examined associations between changes in cognitive diagnoses and symptoms on the Neuropsychiatric Inventory Questionnaire (NPI-Q) and Geriatric Depression Scale (GDS-15).
results1,121 participants converted from NC to MCI; 324 reverted back to NC and 242 progressed to AD dementia. Higher symptoms on the GDS-15 and circumscribed symptom domains on the NPI-Q were associated with conversion from NC to MCI and a decreased likelihood of reversion from MCI to NC. Individuals with higher symptoms on NPI-Q Hyperactivity and Mood items were more likely to progress to AD dementia. DISCUSSION: The temporal instability of MCI can be partially explained by neuropsychiatric symptoms. Individuals with higher levels of specific symptoms are more likely to progress to AD dementia and less likely to revert to NC. Identification and treatment of these symptoms might support cognitive functioning in older adults.
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