ReviewCurrent opinion in pharmacology2018
Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities.
Review in Current opinion in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Heterotopic Ossification: Molecular Drivers, Subtype-Specific Mechanisms, and Translational Therapeutic Advances.Biomolecules · 2026Review
- Macrophage Polarization in Heterotopic Ossification: Inflammation, Osteogenesis, and Emerging Therapeutic Targets.International journal of molecular sciences · 2025Review
- Targeting fibroblasts in pathological bone formation: mechanisms and treatments.Frontiers in cell and developmental biology · 2025Review
- Insights Gained From an Ultrarare Case of Progressive Osseous Heteroplasia With Severe Complications.Cureus · 2025Article
- Involvement of the Wnt/β-catenin signalling pathway in heterotopic ossification and ossification-related diseases.Journal of cellular and molecular medicine · 2024Review
- Article
- KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Macrophages in heterotopic ossification: from mechanisms to therapy.NPJ Regenerative medicine · 2021Review
- Inhibition of IL-17 prevents the progression of traumatic heterotopic ossification.Journal of cellular and molecular medicine · 2021Article
- Review
- Progressive osseous heteroplasia: a case report and literature review.American journal of translational research · 2021Article
- Mechanism of traumatic heterotopic ossification: In search of injury-induced osteogenic factors.Journal of cellular and molecular medicine · 2020Review
- Radiation therapy for the prevention of heterotopic ossification: Efficacy and toxicity of single fraction radiotherapy.Orthopedic reviews · 2020Article
- Diagnosis of Klippel-Trenaunay syndrome and extensive heterotopic ossification in a patient with a femoral fracture: a case report and literature review.BMC musculoskeletal disorders · 2020Review
- Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-γ agonist palovarotene: a case report.BMC musculoskeletal disorders · 2020Article
- Identification of the Biomarkers and Pathological Process of Heterotopic Ossification: Weighted Gene Co-Expression Network Analysis.Frontiers in endocrinology · 2020Article
- Heterotopic ossification in a 7-year-old female patient treated with individualized homeopathy: A case report.Clinical case reports · 2019Article
- Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats.Journal of cellular and molecular medicine · 2019Article
- Inhibition of immune checkpoints prevents injury-induced heterotopic ossification.Bone research · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Heterotopic ossification (HO) involves the formation and accumulation of extraskeletal bone tissue at the expense of local tissues including muscles and connective tissues. There are common forms of HO that are triggered by extensive trauma, burns and other bodily insults, and there are also rare congenital severe forms of HO that occur in children with Fibrodysplasia Ossificans Progressiva or Progressive Osseous Heteroplasia. Given that HO is often preceded by inflammation, current treatments usually involve anti-inflammatory drugs alone or in combination with local irradiation, but are not very effective. Recent studies have provided novel insights into the pathogenesis of acquired and genetic forms of HO and have used the information to conceive and test new and more specific therapies in animal models. In this review, I provide salient examples of these exciting and promising advances that are undoubtedly paving the way toward resolution of this debilitating and at times fatal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.