ReviewNeurobiology of learning and memory2018
Running from fear: Exercise modulation of fear extinction.
Review in Neurobiology of learning and memory, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-Analysis on the Effects of Exercise on the Endocannabinoid System.Cannabis and cannabinoid research · 2022Pooled it
- Exercise-induced increases in Anandamide and BDNF during extinction consolidation contribute to reduced threat following reinstatement: Preliminary evidence from a randomized controlled trial.Psychoneuroendocrinology · 2021Trial
- Electroacupuncture facilitates remote fear memory erasure via promoting perineuronal net degradation.Translational psychiatry · 2025Article
- Adapting digital anxiety treatments to reduce anorexia nervosa relapse.Journal of affective disorders · 2025Article
- High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway.Biology of sex differences · 2025Article
- Fear learning and generalization in youth with early-stage transdiagnostic psychiatric symptoms and the impact of acute exercise.Frontiers in psychiatry · 2025Article
- Pharmacological manipulations of the dorsomedial and dorsolateral striatum during fear extinction reveal opposing roles in fear renewal.Neurobiology of learning and memory · 2024Article
- Exercise and Fear and Safety Learning.Current topics in behavioral neurosciences · 2024Review
- Altered fear engram encoding underlying conditioned versus unconditioned stimulus-initiated memory updating.Science advances · 2023Article
- Aerobic exercise after extinction learning reduces return of fear and enhances memory of items encoded during extinction learning.Mental health and physical activity · 2023Article
- Aerobic exercise in the treatment of PTSD: An examination of preclinical and clinical laboratory findings, potential mechanisms, clinical implications, and future directions.Journal of anxiety disorders · 2023Review
- Impact of Stress and Exercise on Fear Extinction.Current topics in behavioral neurosciences · 2023Article
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- Conceptualizing eating disorder psychopathology using an anxiety disorders framework: Evidence and implications for exposure-based clinical research.Clinical psychology review · 2021Review
- Recent Advances in the Understanding of Specific Efferent Pathways Emerging From the Cerebellum.Frontiers in neuroanatomy · 2021Review
- Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling.Neurobiology of learning and memory · 2020Article
- Effects of exercise on proactive interference in memory: potential neuroplasticity and neurochemical mechanisms.Psychopharmacology · 2020Review
- Sex differences in resilience: Experiential factors and their mechanisms.The European journal of neuroscience · 2020Review
- 3,4-methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats.Physiology & behavior · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear tends to resurface even after successful extinction. Identification of novel strategies to enhance fear extinction and reduce fear relapse is of paramount importance to mental health. Exercise can enhance cognitive function, but it is not yet well understood whether exercise can be an effective augmentation strategy for fear extinction. In the current review, we present the current state of knowledge on the effects of exercise on fear extinction. Effects of exercise duration, explanations for conflicting results, and potential mechanisms, focusing on a hypothesized role for dopamine, are all discussed. We also provide new data suggesting that the timing in which acute exercise occurs relative to fear extinction, is a crucial variable in determining whether exercise can enhance fear extinction. Clinical implications and ideas to guide future research endeavors in this area are provided.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.