ArticlePLoS genetics2018
Identification and characterization of wheat stem rust resistance gene Sr21 effective against the Ug99 race group at high temperature.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Meta-QTLs for multiple disease resistance involving three rusts in common wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- The MdERF1B-miR482c-Horticulture research · 2026Article
- No Cost of Resistance in Wheat Gene Stack Lines Containing 10 Stem Rust Resistance Transgenes.Plant biotechnology journal · 2026Article
- Introgressed Variation in TaMYB7-A1 Drives Graded Dormancy and Climate-Adaptive Pre-Harvest Sprouting Resistance in Wheat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Characterization of Durum-Einkorn Amphiploids for Introgression of Powdery Mildew Resistance from Einkorn into Common Wheat.Pathogens (Basel, Switzerland) · 2026Article
- Genome-assisted identification of wheat leaf rust resistance gene Lr.ace-4A/Lr30.Nature communications · 2025Article
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- Integrated Management Strategies for Blackleg Disease of Canola Amidst Climate Change Challenges.Journal of fungi (Basel, Switzerland) · 2025Review
- Divergent molecular pathways govern temperature-dependent wheat stem rust resistance genes.Nature communications · 2025Article
- Manipulation of the brown glume and internode 1 gene leads to alterations in the colouration of lignified tissues, lignin content and pathogen resistance in wheat.Plant biotechnology journal · 2025Article
- Progress and innovations of gene cloning in wheat and its close relatives.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- A single NLR gene confers resistance to leaf and stripe rust in wheat.Nature communications · 2024Article
- Wheat improvement through advances in single nucleotide polymorphism (SNP) detection and genotyping with a special emphasis on rust resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Mapping and Candidate Gene Analysis of an All-Stage Stem Rust Resistance Gene in Durum Wheat Landrace PI 94701.Plants (Basel, Switzerland) · 2024Article
- Genome-wide atlas of rust resistance loci in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Mapping and characterization of rust resistance genes Lr53 and Yr35 introgressed from Aegilops species.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Pooled effector library screening in protoplasts rapidly identifies novel Avr genes.Nature plants · 2024Article
- Transcriptomics of temperature-sensitive R gene-mediated resistance identifies a WAKL10 protein interaction network.Scientific reports · 2024Article
- Fine mapping ofFrontiers in plant science · 2024Article
- The genetics of Ug99 stem rust resistance in spring wheat variety 'Linkert'.Frontiers in plant science · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wheat stem rust, caused by Puccinia graminis f. sp. tritici (Pgt), is a devastating foliar disease. The Ug99 race group has combined virulence to most stem rust (Sr) resistance genes deployed in wheat and is a threat to global wheat production. Here we identified a coiled-coil, nucleotide-binding leucine-rich repeat protein (NLR) completely linked to the Ug99 resistance gene Sr21 from Triticum monococcum. Loss-of-function mutations and transgenic complementation confirmed that this gene is Sr21. Sr21 transcripts were significantly higher at high temperatures, and this was associated with significant upregulation of pathogenesis related (PR) genes and increased levels of resistance at those temperatures. Introgression of Sr21 into hexaploid wheat resulted in lower levels of resistance than in diploid wheat, but transgenic hexaploid wheat lines with high levels of Sr21 expression showed high levels of resistance. Sr21 can be a valuable component of transgenic cassettes or gene pyramids combining multiple resistance genes against Ug99.
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