ArticleMaterials (Basel, Switzerland)2018
Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells.
Article in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Progress and challenges of tantalum-containing biomaterials in regenerative medicine applications.Journal of materials science. Materials in medicine · 2026Review
- Rapid osteointegration with a strontium-containing hydroxyapatite coating on tantalum by activating Itga6-PI3K/AKT signaling pathway.Materials today. Bio · 2025Article
- Surface modifications of biomaterials in different applied fields.RSC advances · 2023Review
- Preparation, modification, and clinical application of porous tantalum scaffolds.Frontiers in bioengineering and biotechnology · 2023Review
- Stability, biomechanics and biocompatibility analysis following different preparation strategies of hierarchical zeolite coatings on titanium alloy surfaces.Frontiers in bioengineering and biotechnology · 2023Article
- Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review.Frontiers in bioengineering and biotechnology · 2022Review
- Assessment of tantalum nanoparticle-induced MC3T3-E1 proliferation and underlying mechanisms.Journal of materials science. Materials in medicine · 2021Article
- The Effect of Thermal Oxidation on the Photothermal Conversion Property of Tantalum Coatings.Materials (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, tantalum has been attracting much attention for its anticorrosion resistance and biocompatibility, and it has been widely used in surface modification for implant applications. To improve its osteogenic differentiation of human bone marrow stem cells (hBMSCs), a micro/nano structure has been fabricated on the tantalum coating surface through the combination of anodic oxidation and plasma spraying method. The morphology, composition, and microstructure of the modified coating were comprehensively studied by employing scanning electron microscopy (SEM), X-ray diffraction (XRD) as well as transmission electron microscopy (TEM). The effects of hierarchical structures as well as micro-porous structure of tantalum coating on the behavior for human bone marrow stem cells (hBMSCs) were evaluated and compared at both cellular and molecular levels in vitro. The experimental results show that a hierarchical micro/nano structure with Ta₂O₅ nanotubes spread onto a micro-scale tantalum coating has been fabricated successfully, which is confirmed to promote cell adhesion and spreading. Besides, the hierarchical micro/nano tantalum coating can provide 1.5~2.1 times improvement in gene expression, compared with the micro-porous tantalum coating. It demonstrates that it can effectively enhance the proliferation and differentiation of hBMSCs in vitro.
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Registered trials
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