Evidence map›Paper›PMID 29611807›Full record

ArticleeLife2018

CK1/Doubletime activity delays transcription activation in the circadian clock.

Deniz Top, Jenna L O'Neil, Gregory E Merz, Kritika Dusad, Brian R Crane, Michael W Young

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Review
  6. Review
  7. A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Integration of Circadian Clock Information in theJournal of biological rhythms · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. NADMolecular cell · 2020
    Article
  19. Article
  20. Disrupted Glutamate Signaling inFrontiers in physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Deniz TopLaboratory of Genetics, The Rockefeller University, New York, United States.ORCID 0000-0002-1042-8460
Jenna L O'NeilLaboratory of Genetics, The Rockefeller University, New York, United States.
Gregory E MerzDepartment of Chemistry and Chemical Biology, Cornell University, New York, United States.
Kritika DusadDepartment of Chemistry and Chemical Biology, Cornell University, New York, United States.
Brian R CraneDepartment of Chemistry and Chemical Biology, Cornell University, New York, United States.ORCID 0000-0001-8234-9991
Michael W YoungLaboratory of Genetics, The Rockefeller University, New York, United States.
Cornell University · USRockefeller University · US

Funding

Molecular Mechanisms of Signal Transduction Involving Light, Redox and Transmembrane ComplexesR35GM122535 · NIGMS · CORNELL UNIVERSITY · PI BRIAN R CRANE · 2017 to 2026
$7.1M
Molecular and Cellular Studies of Circadian RhythmsR37GM054339 · NIGMS · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 2009 to 2018
$3.8M
MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMSR01GM054339 · NIGMS · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 1997 to 2008
$3.2M
Structure and Function of Circadian Clock Light SensorsR01GM079679 · NIGMS · CORNELL UNIVERSITY · PI CRANE, BRIAN R · 2007 to 2016
$3.1M
NIGMS NIH HHS R01 GM054339NIGMS NIH HHS R01 GM079679NIGMS NIH HHS R35 GM122535NIGMS NIH HHS R37 GM054339NIH HHS GM054339NIH HHS GM079679NIH HHS GM122535
6 · The paper itself

Abstract

In the

Indexed as

Circadian ClocksTranscriptional ActivationAnimalsCasein Kinase 1 epsilonDrosophilaDrosophila ProteinsFeedback, PhysiologicalGene Expression RegulationPeriod Circadian ProteinsCasein Kinase 1 epsilondco protein, DrosophilaDrosophila ProteinsPeriod Circadian ProteinsPER protein, Drosophilatim protein, Drosophilabiochemistrychemical biologycircadian rhythmsD. melanogasterDoubletimeneurosciencephosphorylationprotein degradationtranscription regulation

Identifiers

PMID29611807
PMCPMC5882363
OpenAlexW2796327871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.