ArticleThe American journal of tropical medicine and hygiene2018
Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses.
Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Association of Intestinal Amino Acid Absorption with the Uptake of Lactulose and Rhamnose in Adults with Environmental Enteropathy.The American journal of tropical medicine and hygiene · 2025Article
- Association of feeding practices with growth in infants: a longitudinal observational study in a rural district of Pakistan.BMJ public health · 2025Article
- Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children.The American journal of clinical nutrition · 2024Article
- Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis.The American journal of clinical nutrition · 2024Article
- Association between stunting and fecal calprotectin levels in breastfed infants living in a rural area of the Democratic Republic of the Congo: a cross sectional study.African health sciences · 2024Article
- Article
- NADScience translational medicine · 2024Article
- Quantitative Morphometry and Machine Learning Model to Explore Duodenal and Rectal Mucosal Tissue of Children with Environmental Enteric Dysfunction.The American journal of tropical medicine and hygiene · 2023Article
- Intestinal Epithelial Digestive, Transport, and Barrier Protein Expression Is Increased in Environmental Enteric Dysfunction.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Article
- Intestinal Biopsies for the Evaluation of Environmental Enteropathy and Environmental Enteric Dysfunction.The Journal of infectious diseases · 2021Review
- Diversity and dynamism of IgA-microbiota interactions.Nature reviews. Immunology · 2021Review
- Gut integrity and duodenal enteropathogen burden in undernourished children with environmental enteric dysfunction.PLoS neglected tropical diseases · 2021Article
- Review
- A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth.PLoS neglected tropical diseases · 2020Article
- Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation.BMC pediatrics · 2019Article
- Assessment of Machine Learning Detection of Environmental Enteropathy and Celiac Disease in Children.JAMA network open · 2019Article
- Pathobiome driven gut inflammation in Pakistani children with Environmental Enteric Dysfunction.PloS one · 2019Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Despite nutrition interventions, stunting thought to be secondary to underlying environmental enteropathy (EE) remains pervasive among infants residing in resource-poor countries and remains poorly characterized. From a birth cohort of 380 children, 65 malnourished infants received 12 weeks of nutritional supplementation with ready-to-use therapeutic food (RUTF). Eleven children with insufficient response to RUTF underwent upper endoscopy with duodenal biopsies, which were compared with U.S., age-matched specimens for healthy, celiac disease, non-celiac villous atrophy, non-celiac intraepithelial lymphocytosis, and graft-versus-host disease patients. Of the 11 children biopsied, EE was found in 10 (91%) with one subject with celiac disease. Morphometry demonstrated decreased villus-to-crypt (V:C) ratios in EE relative to healthy and non-celiac lymphocytosis patients. Environmental enteropathy villus volumes were significantly decreased relative to healthy controls. In EE, average CD3
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Registered trials
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