ArticleThe American journal of tropical medicine and hygiene2018
Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain.
Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 28 citations in OpenAlex.
- Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation.Lasers in medical science · 2025Trial
- Short-term outcomes of ulnar, median, tibial, and common fibular neurolysis in leprosy neuropathy: A prospective study of pain, sensory function, and muscle strength.PLoS neglected tropical diseases · 2026Article
- Multimodal approach to the diagnosis of pure neural neuropathy in leprosy.Frontiers in medicine · 2025Article
- Ultrasonography as a diagnostic tool for Neural Pain in Leprosy.PLoS neglected tropical diseases · 2022Article
- Assessment of neuropathic pain in leprosy patients with relapse or treatment failure by infrared thermography: A cross-sectional study.PLoS neglected tropical diseases · 2021Article
- Clinical prediction rules for the diagnosis of neuritis in leprosy.BMC infectious diseases · 2021Article
- Cytokine Levels in Neural Pain in Leprosy.Frontiers in immunology · 2020Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural pain is a frequent symptom in leprosy disease. There is a paucity of data regarding neural pain diagnostics resulting in common prescriptive errors when neuritis is confused with neuropathic or mixed nociceptive-neuropathic pain. The present study identified important demographic, clinical, and neurophysiological features of 42 leprosy neuropathy patients presenting neuropathic pain (NP). During routine evaluations, patients were selected asking if they had ever experienced neural pain. Data analyses of their pain characteristics, clinical examination results, and both the Douleur Neuropathique 4 Questionnaire and Hamilton Depression Scale scores were used to classify these patients. The most common word they used to describe the sensation of pain for 25 (60%) of these patients was "burning." In the early stages of the disease and before leprosy diagnosis, 19 (45%) had already complained about NP and leprosy treatment was unable to prevent its occurrence in 15 (36%). Leprosy reactions, considered NP risk factors, occurred in 32 (76%) cases. Knowledge of typical NP characteristics could be used to develop more effective therapeutic approaches for a notoriously difficult-to-treat pain condition.
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