Evidence map›Paper›PMID 29611334›Full record

ArticlePhysiological reports2018

Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension.

Renfang Song, Laura Kidd, Adam Janssen, Ihor V Yosypiv

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Renin-angiotensin system in mammalian kidney development.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  4. Article
  5. The (pro)renin receptor in health and disease.Nature reviews. Nephrology · 2019
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Renfang SongDepartment of Pediatrics, Tulane University School of Medicine, New Orleans, Los Angeles.
Laura KiddDepartment of Pathology, Tulane University School of Medicine, New Orleans, Los Angeles.
Adam JanssenDepartment of Pediatrics, Tulane University School of Medicine, New Orleans, Los Angeles.
Ihor V YosypivDepartment of Pediatrics, Tulane University School of Medicine, New Orleans, Los Angeles.
Tulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells (NPCs) of the cap mesenchyme (CM) and the ureteric bud (UB). The prorenin receptor (PRR) is a receptor for renin and prorenin, and an accessory subunit of the vacuolar proton pump V-ATPase. Previously, we demonstrated that conditional ablation of the PRR in Six2

Indexed as

HypertensionAnimalsGene Expression Regulation, DevelopmentalKidneyMiceMice, KnockoutNephronsOrganogenesisProrenin ReceptorReceptors, Cell SurfaceStem CellsProrenin ReceptorReceptors, Cell SurfaceDevelopmental programminghypertensionkidney developmentnephrogenesisnephron progenitor cellsprorenin receptor

Identifiers

PMID29611334
PMCPMC5880790
OpenAlexW2796269092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.