Evidence map›Paper›PMID 29611241›Full record

ArticlePsycho-oncology2018

The interactive effect of advanced cancer patient and caregiver prognostic understanding on patients' completion of Do Not Resuscitate orders.

Megan Johnson Shen, Kelly M Trevino, Holly G Prigerson

3 registry-linked trialsAbstract read
In one paragraph

Article in Psycho-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04158908 completednot on this mapstarted 2020, after this paper: background citation

Giving Information Systematically and Transparently in Lung and GI Cancer

TypeobservationalSponsorWeill Medical College of Cornell UniversityRan2020 to 2020Enrolled20ConditionsCritical Illness, Oncology, CommunicationArmsOncolo-GIST
NCT04179305 nacompletednot on this mapstarted 2020, after this paper: background citation

Giving Information Systematically and Transparently in Lung and GI Cancer Phase 2

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2020 to 2023Enrolled37ConditionsCritical Illness, Oncology, CommunicationArmsOncolo-GIST, Usual Care Arm
NCT06067087 completednot on this mapstarted 2023, after this paper: background citation

Prognostic Understanding in Patients Receiving Enhanced Supportive Care (ProgESC Study)

TypeobservationalSponsorUniversity College, LondonRan2023 to 2024Enrolled91ConditionsAdvanced Cancer
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Dyadic-concordance death-preparedness states and end-of-life care received by cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
  5. Prognostic understanding among patients with advanced cancer recently referred to an enhanced supportive care service: results from the cross-sectional ProgESC study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Ethics consultations in neuro-oncology.Neuro-oncology practice · 2021
    Article
  14. Timing of do-not-resuscitate orders and health care utilization near the end of life in cancer patients: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Megan Johnson ShenDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0001-8006-8459
Kelly M TrevinoDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.
Holly G PrigersonDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Psychosocial Approaches to Better Understanding & End-Stage Cancer Care (PROTECT)R35CA197730 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Holly Gwen Prigerson · 2015 to 2026
$11.2M
Quality of Death: Ethnic and Psychosocial InfluencesR01CA106370 · NCI · YALE UNIVERSITY · PI PRIGERSON, HOLLY GWEN · 2004 to 2015
$4.1M
Psychiatric Disorder in Dying Patients &Their SurvivorsR01MH063892 · NIMH · YALE UNIVERSITY · PI JACOBS, SELBY C · 2002 to 2005
$1.9M
Culturally Competent Communication Intervention to Improve Latinos' Engagement in Advance Care PlanningK07CA207580 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHEN, MEGAN JOHNSON · 2017 to 2021
$915k
Anxiety With Cancer in the Elderly (ACE): A Cognitive-Behavioral InterventionK23AG048632 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI MCCONNELL, KELLY · 2014 to 2018
$782k
Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) in Caregivers of ICU Cancer PatientsR21CA218313 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LICHTENTHAL, WENDY G., PRIGERSON, HOLLY GWEN · 2017 to 2018
$422k
NCATS NIH HHS UL1 TR002384NCI NIH HHS K07 CA207580NCI NIH HHS R01 CA106370NCI NIH HHS R21 CA218313NCI NIH HHS R35 CA197730NIA NIH HHS K23 AG048632NIMH NIH HHS R01 MH063892
6 · The paper itself

Abstract

objectiveAdvanced cancer patients' prognostic understanding is associated with completion of Do Not Resuscitate (DNR) orders, which often represent engagement in advance care planning (ACP). Given caregivers' critical roles in patient decision-making about ACP and end-of-life care, caregivers' prognostic understanding may have a large additive effect. The present study examined the association between the main and interactive effects of advanced cancer patient and caregiver prognostic understanding on DNR order completion.

methodsData were analyzed from a combined dataset of 2 sequential multi-institutional, longitudinal cohort studies of patients with advanced cancer and their informal caregivers (n = 279 dyads) from 2002 to 2008 (Coping with Cancer 1) and 2010 to 2015 (Coping with Cancer 2). Patients' and caregivers' prognostic understanding regarding life-expectancy (≤ 12 months [prognostic understanding], >12 months [lack of prognostic understanding]) was assessed. DNR order completion was assessed through self-report and confirmed through cross-checking with medical records.

resultsMultivariable modeling of the main and interactive effects revealed the interactive effect, but not the individual effects, of patients' and caregivers' prognostic understanding was significantly associated with higher odds of patients' DNR order completion, adjusting for potential confounds (AOR = 5.89, P = 0.04). For dyads in which both the patient and caregiver had prognostic understanding regarding life expectancy of ≤12 months, 70.7% of patients had completed DNR orders compared with 31.6% to 38.9% in which 1 or both lacked prognostic understanding.

conclusionsFindings highlight the need for ensuring accurate patient and caregiver prognostic understanding in increasing DNR order completion, which may provide a framework for improving engagement in ACP more broadly.

Indexed as

Adaptation, PsychologicalAdultAdvance Care PlanningAdvance DirectivesAgedCaregiversCohort StudiesDecision MakingFemaleHumansLongitudinal StudiesMaleMiddle AgedNeoplasmsResuscitation OrdersTerminal Careadvanced cancercancer caregiversDo-Not-Resuscitate (DNR) orderend of lifeprognostic accuracy

Identifiers

PMID29611241
PMCPMC6589346

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.