Evidence map›Paper›PMID 29611100›Full record

ArticleMolecular neurobiology2018

Resveratrol Acts Anti-Inflammatory and Neuroprotective in an Infant Rat Model of Pneumococcal Meningitis by Modulating the Hippocampal miRNome.

Karina Barbosa de Queiroz, Thaís Dos Santos Fontes Pereira, Márcio Sobreira Silva Araújo, Ricardo Santiago Gomez, Roney Santos Coimbra

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

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  16. The Protective Effect ofNutrients · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Karina Barbosa de QueirozImunopatologia / Neurogenômica, Instituto René Rachou, Fiocruz-Minas, Av. Augusto de Lima, 1715 - Barro Preto, Belo Horizonte, MG, 30190-002, Brazil.ORCID http://orcid.org/0000-0002-8171-435X
Thaís Dos Santos Fontes PereiraDepartamento de Cirurgia Oral e Patologia, Escola de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Márcio Sobreira Silva AraújoGrupo Integrado de Pesquisas em Biomarcadores, Instituto René Rachou, Fiocruz-Minas, Belo Horizonte, Brazil.
Ricardo Santiago GomezDepartamento de Cirurgia Oral e Patologia, Escola de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Roney Santos CoimbraImunopatologia / Neurogenômica, Instituto René Rachou, Fiocruz-Minas, Av. Augusto de Lima, 1715 - Barro Preto, Belo Horizonte, MG, 30190-002, Brazil. roney.s.coimbra@minas.fiocruz.br.
Universidade Federal de Minas Gerais · BRFundação Oswaldo Cruz · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 400046/2013-0Fundação de Amparo à Pesquisa do Estado de Minas Gerais CBB-APQ-0266114
6 · The paper itself

Abstract

Resveratrol (RSV) is anti-inflammatory and neuroprotective, cross the blood-brain barrier (BBB) and has a safe profile. Besides, RSV modulates the expression of some miRNAs related to neurological disorders. Thus, we hypothesized that RSV can be neuroprotective in pneumococcal meningitis by modulating the global microRNA expression profile (miRNome). Eleven-day old rats were intracysternally infected with S. pneumoniae (~ 2 × 10

Indexed as

AnimalsAnimals, NewbornAnti-Inflammatory AgentsApoptosisBiomarkersChemokine CCL2Chemokine CCL3Cluster AnalysisDisease Models, AnimalGene Expression ProfilingHippocampusInterleukin-1betaMeningitis, PneumococcalMicroRNAsModels, BiologicalNeuronsAnti-Inflammatory AgentsBiomarkersChemokine CCL2Chemokine CCL3Interleukin-1betaMicroRNAsNeuroprotective AgentsResveratrolTranscription FactorsMeningitismicroRNAmiRNomeNeuroprotectionResveratrolStreptococcus pneumoniae

Identifiers

PMID29611100
OpenAlexW2795555810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.