ArticleMarine biotechnology (New York, N.Y.)2018
Metabolomics Study of Immune Responses of New Zealand Greenshell™ Mussels (Perna canaliculus) Infected with Pathogenic Vibrio sp.
Article in Marine biotechnology (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 100 citations in OpenAlex.
- Microalgae Parasite Diseases ofAntioxidants (Basel, Switzerland) · 2025Article
- Effects of in situ experimental warming on metabolic expression in a soft sediment bivalve.Scientific reports · 2025Article
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- Metabolomic signatures of corals thriving across extreme reef habitats reveal strategies of heat stress tolerance.Proceedings. Biological sciences · 2023Article
- Mussel mass mortality in the Clinch River, USA: metabolomics detects affected pathways and biomarkers of stress.Conservation physiology · 2023Article
- Metabolite profiling of abalone (Haliotis iris) energy metabolism: a Chatham Islands case study.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Investigating the biochemical effects of heat stress and sample quenching approach on the metabolic profiling of abalone (Haliotis iris).Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Article
- Beyond relaxed: magnesium chloride anaesthesia alters the circulatory metabolome of a marine mollusc (Perna canaliculus).Metabolomics : Official journal of the Metabolomic Society · 2021Article
- An integrated omics approach to investigate summer mortality of New Zealand Greenshell™ mussels.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Review
- Metabolic response ofPeerJ · 2020Article
- Perturbations of Metabolomic Profiling of Spleen From Rats Infected WithFrontiers in molecular biosciences · 2020Article
- Mechanistic molecular responses of the giant clam Tridacna crocea to Vibrio coralliilyticus challenge.PloS one · 2020Article
- Differential Transcriptomic and Metabolomic Responses in the Liver of Nile Tilapia (Oreochromis niloticus) Exposed to Acute Ammonia.Marine biotechnology (New York, N.Y.) · 2019Article
- Targeted metabolomics to investigate antimicrobial activity of itaconic acid in marine molluscs.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Itaconic acid inhibits growth of a pathogenic marine Vibrio strain: A metabolomics approach.Scientific reports · 2019Article
- Dual Analysis of Virus-Host Interactions: The Case ofEvolutionary bioinformatics online · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio coralliilyticus is a bacterial pathogen which can affect a range of marine organisms, such as corals, fish and shellfish, with sometimes devastating consequences. However, little is known about the mechanisms involved in the host-pathogen interaction, especially within molluscan models. We applied gas chromatography-mass spectrometry (GC-MS)-based metabolomics to characterize the physiological responses in haemolymph of New Zealand Greenshell™ mussels (Perna canaliculus) injected with Vibrio sp. DO1 (V. coralliilyticus/neptunius-like isolate). Univariate data analyses of metabolite profiles in Vibrio-exposed mussels revealed significant changes in 22 metabolites at 6 h post-infection, compared to non-exposed mussels. Among them, 10 metabolites were up-regulated, while 12 metabolites were down-regulated in infected mussels. Multivariate analyses showed a clear distinction between infected and non-infected mussels. In addition, secondary pathway analyses indicated perturbations of the host innate immune system following infection, including oxidative stress, inflammation and disruption of the TCA cycle, change in amino acid metabolism and protein synthesis. These findings provide new insights into the pathogenic mechanisms of Vibrio infection of mussels and demonstrate our ability to detect detailed and rapid host responses from haemolymph samples using a metabolomics approach.
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