Evidence map›Paper›PMID 29610671›Full record

ReviewCerebellum & ataxias2018

The mystery of the cerebellum: clues from experimental and clinical observations.

Charlotte Lawrenson, Martin Bares, Anita Kamondi, Andrea Kovács, Bridget Lumb, Richard Apps, Pavel Filip, Mario Manto

Open access · hybridAbstract readReview
In one paragraph

Review in Cerebellum & ataxias, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

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  16. Cell Type-specific Knockout withExperimental neurobiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Charlotte Lawrenson1School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol, Tankard's Close, University Walk, Bristol, BS8 1TD UK.
Martin Bares2First Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne's Teaching Hospital, Brno, Czech Republic.
Anita Kamondi4Department of Neurology, National Institute of Clinical Neurosciences, Amerikai út 57, Budapest, 1145 Hungary.
Andrea Kovács4Department of Neurology, National Institute of Clinical Neurosciences, Amerikai út 57, Budapest, 1145 Hungary.
Bridget Lumb1School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol, Tankard's Close, University Walk, Bristol, BS8 1TD UK.
Richard Apps1School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol, Tankard's Close, University Walk, Bristol, BS8 1TD UK.
Pavel Filip2First Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne's Teaching Hospital, Brno, Czech Republic.
Mario Manto7FNRS ULB-Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium.
University of Bristol · GBMasaryk University · CZOrszágos Idegsebészeti Tudományos Intézet · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebellum has a striking homogeneous cytoarchitecture and participates in both motor and non-motor domains. Indeed, a wealth of evidence from neuroanatomical, electrophysiological, neuroimaging and clinical studies has substantially modified our traditional view on the cerebellum as a sole calibrator of sensorimotor functions. Despite the major advances of the last four decades of cerebellar research, outstanding questions remain regarding the mechanisms and functions of the cerebellar circuitry. We discuss major clues from both experimental and clinical studies, with a focus on rodent models in fear behaviour, on the role of the cerebellum in motor control, on cerebellar contributions to timing and our appraisal of the pathogenesis of cerebellar tremor. The cerebellum occupies a central position to optimize behaviour, motor control, timing procedures and to prevent body oscillations. More than ever, the cerebellum is now considered as a major actor on the scene of disorders affecting the CNS, extending from motor disorders to cognitive and affective disorders. However, the respective roles of the mossy fibres, the climbing fibres, cerebellar cortex and cerebellar nuclei remains unknown or partially known at best in most cases. Research is now moving towards a better definition of the roles of cerebellar modules and microzones. This will impact on the management of cerebellar disorders.

Indexed as

AnatomyCerebellumCognitionFearHistoryMotorTimingTremor

Identifiers

PMID29610671
PMCPMC5877388
OpenAlexW2803217360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.