ArticleBiotechnology for biofuels2018
Techno-economic analysis of the industrial production of a low-cost enzyme using
Article in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 171 citations in OpenAlex.
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- Developing a simple, cost-effective proof-of-concept vaccine candidate against EHEC for cattle.PloS one · 2026Article
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- Impact of biomanufacturing protein fibers on achieving sustainable development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- From Waste to Wealth: Unlocking the Potential of Cellulase Characteristics for Food Processing Waste Management.Foods (Basel, Switzerland) · 2025Review
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- Green Purification of Invertase from Ultrasonicated Sifted Baker's Yeast by Membrane Filtration: A Comparative Study.Molecules (Basel, Switzerland) · 2025Article
- Enhancing recombinant growth factor and serum protein production for cultivated meat manufacturing.Microbial cell factories · 2025Review
- FACS-Sortable Triple Emulsion Picoreactors for Screening Reactions in Biphasic Environments.Advanced materials interfaces · 2025Article
- Tuning and functionalization of logic gates for time resolved programming of bacterial populations.Nucleic acids research · 2025Article
- Increased cytoplasmic expression of PETase enzymes in E. coli.Microbial cell factories · 2024Article
- Cloning, heterologous expression and characterization of β-glucosidase deriving from3 Biotech · 2024Article
- Omic-driven strategies to unveil microbiome potential for biodegradation of plastics: a review.Archives of microbiology · 2024Review
- Comparative evaluation of the extracellular production of a polyethylene terephthalate degrading cutinase by Corynebacterium glutamicum and leaky Escherichia coli in batch and fed-batch processes.Microbial cell factories · 2024Article
- A new halotolerant xylanase from3 Biotech · 2024Article
- Enhanced Production of Erythritol from Glucose by the Newly Obtained UV MutantMolecules (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe enzymatic conversion of lignocellulosic biomass into fermentable sugars is a promising approach for producing renewable fuels and chemicals. However, the cost and efficiency of the fungal enzyme cocktails that are normally employed in these processes remain a significant bottleneck. A potential route to increase hydrolysis yields and thereby reduce the hydrolysis costs would be to supplement the fungal enzymes with their lacking enzymatic activities, such as β-glucosidase. In this context, it is not clear from the literature whether recombinant
resultsIn a simulated baseline scenario for β-glucosidase demand in a hypothetical second-generation ethanol (2G) plant in Brazil, we found that the production cost (316 US$/kg) was higher than what is commonly assumed in the literature for fungal enzymes, owing especially to the facility-dependent costs (45%) and to consumables (23%) and raw materials (25%). Sensitivity analyses of process scale, inoculation volume, and volumetric productivity indicated that optimized conditions may promote a dramatic reduction in enzyme cost and also revealed the most relevant factors affecting production costs.
conclusionsDespite the considerable technical and economic uncertainties that surround 2G ethanol and the large-scale production of low-cost recombinant enzymes, this work sheds light on some relevant questions and supports future studies in this field. In particular, we conclude that process optimization, on many fronts, may strongly reduce the costs of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.