ArticleJournal of clinical biochemistry and nutrition2018
Dietary intake of inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus.
Article in Journal of clinical biochemistry and nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The impact of dietary phosphorus supplementation on postprandial metabolic outcomes: a systematic review.Journal of nutritional science · 2026Pooled it
- Postprandial serum phosphorus and calcium concentrations in adults and children with X-linked hypophosphatemia during burosumab treatment.JBMR plus · 2026Trial
- Inorganic phosphate: a link between processed food and exercise intolerance in the modern world.Clinical science (London, England : 1979) · 2026Review
- Dietary phosphorus intake and its association with metabolic syndrome and its components: a cross-sectional analysis of the UK national diet and nutrition survey (NDNS).European journal of nutrition · 2026Article
- A Rapid Colorimetric Method for Determining Calcium, Inorganic Phosphorus, and Zinc in Human Milk Using Clinical Laboratory Reagents.Journal of clinical laboratory analysis · 2026Article
- Article
- Organic phosphate but not inorganic phosphate regulatesiScience · 2024Article
- Article
- Association between serum phosphorus and mortality in NHANES 2003-2006: the effect of gender and renal function.Journal of nephrology · 2022Article
- Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis.Kidney international reports · 2021Article
- The effect of dietary phosphorus load and food matrix on postprandial serum phosphate in hemodialysis patients: a pilot study.HRB open research · 2021Article
- High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice.Scientific reports · 2020Article
- Effects of dietary fiber on vascular calcification by repetitive diet-induced fluctuations in plasma phosphorus in early-stage chronic kidney disease rats.Journal of clinical biochemistry and nutrition · 2020Article
- Effects of repetitive diet-induced fluctuations in plasma phosphorus on vascular calcification and inflammation in rats with early-stage chronic kidney disease.Journal of clinical biochemistry and nutrition · 2020Article
- Pathobiological Mechanisms of Endothelial Dysfunction Induced byInternational journal of medical sciences · 2020Article
- Phosphate, the forgotten mineral in hypertension.Current opinion in nephrology and hypertension · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus management through dietetic therapy is vital for the prevention of cardiovascular disease in chronic kidney disease patients. There are two main sources of phosphorus in the diet, organic phosphorus from protein and inorganic phosphorus from food additives. The adverse effects of high phosphorus intake on vascular-endothelium function have been reported; however, the differences in the effects of organic phosphorus versus inorganic phosphorus are not clear. In this study, we examined an acute effect of these high phosphorus meals intake on vascular-endothelium function. This was a randomized, double-blind, cross-over test study design targeting healthy young men. We conducted a food intake test using two test meals, one high in organic phosphorus from organic food sources, and one high in inorganic phosphorus from food additives. Endothelium-dependent vasodilation, phosphorus and calcium in the urine and blood, and phosphorus-related hormones were measured preprandial to 120 min postprandial. The results showed higher serum and urine phosphorus values after the high inorganic phosphorus meal, and a significant reduction in endothelium-dependent vasodilation at 30 min postprandial. These findings are evidence that inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus.
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Registered trials
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