ArticleNature microbiology2018
Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut.
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 198 citations in OpenAlex.
- Designing fiber-gut microbiome interactions with active learning.Nature chemical biology · 2026Article
- Dual human milk oligosaccharide-fibre utilisation is a selection cue for the weaning gut microbiome.Nature communications · 2026Observational
- Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages.Science advances · 2026Article
- A twin xanthan lyase-dependent xanthan degradation system in Paenibacillus taichungensis I5.Applied microbiology and biotechnology · 2026Article
- Niche specialization and cross-feeding interactions shaping gut microbial fiber degradation in a model omnivore.bioRxiv : the preprint server for biology · 2026Article
- Interbacterial warfare in the human gut: insights from Bacteroidales' perspective.Gut microbes · 2025Review
- A single residue affects the dynamics and shape of a tetrameric GH43 β-1,4-d-xylosidase from Levilactobacillus brevis DSM1269.Protein science : a publication of the Protein Society · 2025Article
- Structural and biochemical basis for activity of Aspergillus nidulans α-1,3-glucanases from glycoside hydrolase family 71.Communications biology · 2025Article
- mKmer: an unbiased K-mer embedding of microbiomic single-microbe RNA sequencing data.Briefings in bioinformatics · 2025Article
- Dynamic Impacts of Stock Enhancement on Kaluga Sturgeon (International journal of molecular sciences · 2025Article
- AlleviatingAnimals : an open access journal from MDPI · 2025Article
- Production of cello-oligosaccharides from corncob residue by degradation-synthesis reactions.Applied microbiology and biotechnology · 2024Article
- Current models in bacterial hemicellulase-encoding gene regulation.Applied microbiology and biotechnology · 2024Review
- Impacts of ectoparasite flea infestation on gut microbiota of the Meriones unguiculatus in a rodent-flea system.Parasitology research · 2024Article
- Article
- Purified fibers in chemically defined synthetic diets destabilize the gut microbiome of an omnivorous insect model.bioRxiv : the preprint server for biology · 2024Article
- 3D printed spiral tube-like cellulose scaffold for oral delivery of probiotics.Science advances · 2024Article
- Sulfated Polysaccharides from Sea Cucumber Cooking Liquid Prevents Obesity by Modulating Gut Microbiome, Transcriptome, and Metabolite Profiles in Mice Fed a High-Fat Diet.Foods (Basel, Switzerland) · 2024Article
- Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health.NPJ biofilms and microbiomes · 2024Review
- Identification of carbohydrate gene clusters obtained from in vitro fermentations as predictive biomarkers of prebiotic responses.BMC microbiology · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolism of dietary glycans is pivotal in shaping the human gut microbiota. However, the mechanisms that promote competition for glycans among gut commensals remain unclear. Roseburia intestinalis, an abundant butyrate-producing Firmicute, is a key degrader of the major dietary fibre xylan. Despite the association of this taxon to a healthy microbiota, insight is lacking into its glycan utilization machinery. Here, we investigate the apparatus that confers R. intestinalis growth on different xylans. R. intestinalis displays a large cell-attached modular xylanase that promotes multivalent and dynamic association to xylan via four xylan-binding modules. This xylanase operates in concert with an ATP-binding cassette transporter to mediate breakdown and selective internalization of xylan fragments. The transport protein of R. intestinalis prefers oligomers of 4-5 xylosyl units, whereas the counterpart from a model xylan-degrading Bacteroides commensal targets larger ligands. Although R. intestinalis and the Bacteroides competitor co-grew in a mixed culture on xylan, R. intestinalis dominated on the preferred transport substrate xylotetraose. These findings highlight the differentiation of capture and transport preferences as a possible strategy to facilitate co-growth on abundant dietary fibres and may offer a unique route to manipulate the microbiota based on glycan transport preferences in therapeutic interventions to boost distinct taxa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.