Evidence map›Paper›PMID 29610508›Full record

GuidelineThe American journal of gastroenterology2018

ACG Clinical Guideline: Management of Crohn's Disease in Adults.

Gary R Lichtenstein, Edward V Loftus, Kim L Isaacs, Miguel D Regueiro, Lauren B Gerson, Bruce E Sands

Erratum issuedAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 734 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
734citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

734 citing papers in PubMed, 17 syntheses or guidelines pooled it.

  1. Pooled it
  2. Perianal fistulizing Crohn's disease: Clinical practice update from Colitis and Crohn's Foundation (India).Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Guideline
  3. Pooled it
  4. Online information on bowel resection for Crohn's disease.Annals of the Royal College of Surgeons of England · 2026
    Pooled it
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  6. Diagnosis and Management of Upper Gastrointestinal Involvement in Adult Patients With Crohn's Disease: A Systematic Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Pooled it
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  15. Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  16. Pooled it
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  18. Trial
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674 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Gary R LichtensteinDepartment of Medicine, Division of Gastroenterology, Hospital of the University of Pennsylvania, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Edward V LoftusDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Kim L IsaacsDepartment of Medicine, Division of Gastroenterology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
Miguel D RegueiroDepartment of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA.
Lauren B GersonDepartment of Medicine, Division of Gastroenterology, California Pacific Medical Center, San Francisco, California, USA.
Bruce E SandsDr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crohn's disease is an idiopathic inflammatory disorder of unknown etiology with genetic, immunologic, and environmental influences. The incidence of Crohn's disease has steadily increased over the past several decades. The diagnosis and treatment of patients with Crohn's disease has evolved since the last practice guideline was published. These guidelines represent the official practice recommendations of the American College of Gastroenterology and were developed under the auspices of the Practice Parameters Committee for the management of adult patients with Crohn's disease. These guidelines are established for clinical practice with the intent of suggesting preferable approaches to particular medical problems as established by interpretation and collation of scientifically valid research, derived from extensive review of published literature. When exercising clinical judgment, health-care providers should incorporate this guideline along with patient's needs, desires, and their values in order to fully and appropriately care for patients with Crohn's disease. This guideline is intended to be flexible, not necessarily indicating the only acceptable approach, and should be distinguished from standards of care that are inflexible and rarely violated. To evaluate the level of evidence and strength of recommendations, we used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. The Committee reviews guidelines in depth, with participation from experienced clinicians and others in related fields. The final recommendations are based on the data available at the time of the production of the document and may be updated with pertinent scientific developments at a later time.

Indexed as

AdalimumabAdrenal Cortex HormonesAntibodies, MonoclonalCertolizumab PegolCrohn DiseaseDisease ProgressionEndoscopy, GastrointestinalFecesGastrointestinal AgentsHumansImmunologic FactorsInfliximabIntestinal FistulaLeukocyte L1 Antigen ComplexMagnetic Resonance ImagingMaintenance ChemotherapyAdalimumabAdrenal Cortex HormonesAntibodies, MonoclonalCertolizumab PegolGastrointestinal AgentsImmunologic FactorsInfliximabLeukocyte L1 Antigen ComplexMesalamineTumor Necrosis Factor-alpha

Identifiers

PMID29610508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.