Evidence map›Paper›PMID 29610484›Full record

ArticleNature chemical biology2018

FINO

Michael M Gaschler, Alexander A Andia, Hengrui Liu, Joleen M Csuka, Brisa Hurlocker, Christopher A Vaiana, Daniel W Heindel, Dylan S Zuckerman, Pieter H Bos, Eduard Reznik and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 433 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
433citing papers in PubMed, 1 pooled it
40.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

433 citing papers in PubMed, 1 synthesis or guideline pooled it, 700 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Ferroptosis in cancer: molecular mechanisms, biological roles, and therapeutic significance.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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373 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Michael M GaschlerDepartment of Chemistry, Columbia University, New York, NY, USA.
Alexander A AndiaDepartment of Chemistry, New York University, New York, NY, USA.
Hengrui LiuDepartment of Chemistry, Columbia University, New York, NY, USA.
Joleen M CsukaDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Brisa HurlockerDepartment of Chemistry, New York University, New York, NY, USA.
Christopher A VaianaDepartment of Chemistry, New York University, New York, NY, USA.
Daniel W HeindelDepartment of Chemistry, New York University, New York, NY, USA.
Dylan S ZuckermanDepartment of Chemistry, New York University, New York, NY, USA.
Pieter H BosDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-8710-4771
Eduard ReznikDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Ling F YeDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Yulia Y TyurinaDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Annie J LinDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Mikhail S ShchepinovRetrotope Inc, Los Altos, CA, USA.
Amy Y ChanDepartment of Chemistry, New York University, New York, NY, USA.
Eveliz Peguero-PereiraDepartment of Chemistry, New York University, New York, NY, USA.
Maksim A FomichInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Jacob D DanielsDepartment of Pharmacology, Columbia University, New York, NY, USA.
Andrei V BekishDepartment of Chemistry, Belarusian State University, Minsk, Belarus.
Vadim V ShmanaiInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.ORCID http://orcid.org/0000-0003-1775-8101
Valerian E KaganDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Lara K MahalDepartment of Chemistry, New York University, New York, NY, USA.
K A WoerpelDepartment of Chemistry, New York University, New York, NY, USA. kwoerpel@nyu.edu.
Brent R StockwellDepartment of Chemistry, Columbia University, New York, NY, USA. bstockwell@columbia.edu.
Columbia University · USNew York University · USNational Academy of Sciences of Belarus · BYUniversity of Pittsburgh · USBelarusian State University · BYRetrotope (United States) · US

Funding

Training and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENBERGER, JOEL S · 2005 to 2019
$44.4M
Scientific ReagentsP01CA087497 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PRIVES, CAROL · 2000 to 2021
$35.4M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Defining the functions and translational potential of ferroptosisR35CA209896 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R. · 2016 to 2022
$6.5M
TRAINING PROGRAM IN MOLECULAR BIOPHYSICST32GM008281 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PALMER, ARTHUR G · 1988 to 2017
$5.4M
Lipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8M
New Methods for the Synthesis of Biologically Active PeroxidesR01GM118730 · NIGMS · NEW YORK UNIVERSITY · PI WOERPEL, KEITH ALLEN · 2017 to 2020
$1.3M
NCI NIH HHS P01 CA087497NCI NIH HHS R01 CA165065NCI NIH HHS R35 CA209896NHLBI NIH HHS P01 HL114453NIAID NIH HHS U19 AI068021NIGMS NIH HHS R01 GM118730NIGMS NIH HHS T32 GM008281
6 · The paper itself

Abstract

Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO

Indexed as

ApoptosisAnimalsCarbolinesCell Line, TumorColorimetryDioxolanesEndoplasmic ReticulumGlutathioneGlutathione PeroxidaseHomeostasisHumansIronLipid PeroxidationMiceMicrosomesNADPCarbolinesDioxolaneserastinformal glycolGlutathioneGlutathione PeroxidaseIronNADPPhospholipid Hydroperoxide Glutathione PeroxidasePiperazinesRSL3 compound

Identifiers

PMID29610484
PMCPMC5899674
OpenAlexW2795028304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.