Evidence map›Paper›PMID 29610404›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury.

Line Heylen, Bernard Thienpont, Maarten Naesens, Pieter Busschaert, Jeroen Depreeuw, Dominiek Smeets, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne, Evelyne Lerut and 4 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01331668 (Biobank Renal Transplantation University Hospitals Leuven), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01331668 recruitingnot on this map

Biobank Renal Transplantation University Hospitals Leuven

TypeobservationalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2004 to 2099Enrolled5,000ConditionsKidney Failure
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Article
  6. Article
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  14. Role of novel biomarkers in kidney transplantation.World journal of transplantation · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Emerging strategies to disrupt the central TGF-β axis in kidney fibrosis.Translational research : the journal of laboratory and clinical medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Line HeylenDepartments of Nephrology.ORCID 0000-0002-4595-0195
Bernard ThienpontLaboratory for Translational Genetics, Department of Human Genetics, and.ORCID 0000-0002-8772-6845
Maarten NaesensDepartments of Nephrology.
Pieter BusschaertVIB Center for Cancer Biology, VIB, Leuven, Belgium.
Jeroen DepreeuwVIB Center for Cancer Biology, VIB, Leuven, Belgium.
Dominiek SmeetsLaboratory for Translational Genetics, Department of Human Genetics, and.
Ina JochmansAbdominal Transplantation, Department of Microbiology and Immunology.
Diethard MonbaliuAbdominal Transplantation, Department of Microbiology and Immunology.
Jacques PirenneAbdominal Transplantation, Department of Microbiology and Immunology.
Evelyne LerutPathology, University Hospitals Leuven, Leuven, Belgium.
Bart GhesquiereVIB Center for Cancer Biology, VIB, Leuven, Belgium.
Dirk KuypersDepartments of Nephrology.
Diether LambrechtsLaboratory for Translational Genetics, Department of Human Genetics, and diether.lambrechts@kuleuven.vib.be.
Ben SprangersDepartments of Nephrology.
VIB-KU Leuven Center for Cancer Biology · BEUrology Team · USPediatric Nephrology of Alabama · USKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationKidney Transplantation5-MethylcytosineAdultAgedAllograftsCold IschemiaCpG IslandsCross-Sectional StudiesDioxygenasesDNA-Binding ProteinsFemaleFibrosisGene ExpressionGlomerulosclerosis, Focal SegmentalHumans5-hydroxymethylcytosine5-MethylcytosineDioxygenasesDNA-Binding ProteinsMixed Function OxygenasesProto-Oncogene ProteinsTET1 protein, humanTET2 protein, humanTET3 protein, humanchronic allograft nephropathyDNA methylationepigeneticsfibrosisischemiarenal transplantation

Identifiers

PMID29610404
PMCPMC5967765
OpenAlexW2796456547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.