Evidence map›Paper›PMID 29610391›Full record

ArticleCold Spring Harbor molecular case studies2018

Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma.

Rebecca Ronsley, S Rod Rassekh, Yaoqing Shen, Anna F Lee, Colleen Jantzen, Jessica Halparin, Catherine Albert, Douglas S Hawkins, Shazhan Amed, Ralph Rothstein and 8 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Rebecca RonsleyDivision of Endocrinology and Metabolism, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.ORCID 0000-0003-3961-3042
S Rod RassekhBC Children's Hospital Research Institute, Vancouver, British Columbia V5Z 4H4, Canada.ORCID 0000-0001-8005-2641
Yaoqing ShenCanada's Michael Smith Genome Science Centre, British Columbia Cancer, Vancouver, British Columbia V5Z 4S6, Canada.ORCID 0000-0002-7978-0008
Anna F LeeDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Colleen JantzenDivision of Oncology and Hematology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.ORCID 0000-0002-9708-0187
Jessica HalparinDivision of Oncology and Hematology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Catherine AlbertDivision of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98105, USA.ORCID 0000-0002-8101-9066
Douglas S HawkinsDivision of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98105, USA.ORCID 0000-0002-5983-921X
Shazhan AmedDivision of Endocrinology and Metabolism, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Ralph RothsteinDivision of Endocrinology and Metabolism, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Andrew J MungallCanada's Michael Smith Genome Science Centre, British Columbia Cancer, Vancouver, British Columbia V5Z 4S6, Canada.ORCID 0000-0002-0905-2742
David DixDivision of Oncology and Hematology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Geoffrey BlairDepartment of Surgery, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Helen NadelDepartment of Radiology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.ORCID 0000-0003-0236-7298
Steven J M JonesCanada's Michael Smith Genome Science Centre, British Columbia Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Janessa LaskinBritish Columbia Cancer, Vancouver, British Columbia V5Z 4S6, Canada.ORCID 0000-0002-0161-9329
Marco A MarraCanada's Michael Smith Genome Science Centre, British Columbia Cancer, Vancouver, British Columbia V5Z 4S6, Canada.ORCID 0000-0001-7146-7175
Rebecca J DeyellBC Children's Hospital Research Institute, Vancouver, British Columbia V5Z 4H4, Canada.ORCID 0000-0003-3315-4383
University of British Columbia · CACanada's Michael Smith Genome Sciences Centre · CASeattle Children's Hospital · USBC Cancer Agency · CA

Funding

Cancer transcriptome characterization using massively parallel DNA sequencingU24CA143866 · NCI · BRITISH COLUMBIA CANCER AGENCY · PI MARRA, MARCO ANTONIO · 2009 to 2015
$10.9M
NCI NIH HHS U24 CA143866
6 · The paper itself

Abstract

Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A

Indexed as

Biomarkers, TumorGenomicsAllelesChildGenome-Wide Association StudyGenotypeHumansMaleMolecular Targeted TherapyMutationOncogene Proteins, FusionPositron Emission Tomography Computed TomographyThyroid Cancer, PapillaryTomography, X-Ray ComputedBiomarkers, TumorOncogene Proteins, Fusionmetastatic angiosarcomapapillary thyroid carcinoma

Identifiers

PMID29610391
PMCPMC5880264
OpenAlexW2890751747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.