Evidence map›Paper›PMID 29610310›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Microbes vs. chemistry in the origin of the anaerobic gut lumen.

Elliot S Friedman, Kyle Bittinger, Tatiana V Esipova, Likai Hou, Lillian Chau, Jack Jiang, Clementina Mesaros, Peder J Lund, Xue Liang, Garret A FitzGerald and 6 more

Erratum issuedOpen access · bronzeAbstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 155 papers.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 267 citations in OpenAlex.

  1. Trial
  2. EnterotoxigenicProceedings of the National Academy of Sciences of the United States of America · 2018
    Trial
  3. Review
  4. Article
  5. Review
  6. Article
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  8. Article
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  10. Review
  11. Article
  12. Article
  13. Article
  14. AnmSystems · 2026
    Article
  15. Review
  16. Article
  17. Infection strategies ofGut microbes reports · 2026
    Review
  18. Review
  19. Gut Morphological Structure-Microbial Characteristics inAnimals : an open access journal from MDPI · 2025
    Article
  20. Review

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Elliot S FriedmanDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-0050-4965
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Tatiana V EsipovaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Likai HouDepartment of Chemical and Biomolecular Engineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Lillian ChauDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Jack JiangDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Clementina MesarosInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Peder J LundDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Xue LiangDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Garret A FitzGeraldDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Mark GoulianDepartment of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104.
Daeyeon LeeDepartment of Chemical and Biomolecular Engineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Benjamin A GarciaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ian A BlairInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sergei A VinogradovDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; vinograd@pennmedicine.upenn.edu gdwu@pennmedicine.upenn.edu.
Gary D WuDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; vinograd@pennmedicine.upenn.edu gdwu@pennmedicine.upenn.edu.
University of Pennsylvania · USTranslational Therapeutics (United States) · USChildren's Hospital of Philadelphia · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5M
IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1M
Environmental Science Project 3 - Social Determinants of Risk and Attitudes AboutP42ES023720 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI BLAIR, IAN ALEXANDER · 2014 to 2018
$11.3M
Viral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4M
Regulation of Bacterial Two-Component Signaling by Small Membrane ProteinsR01GM080279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2007 to 2020
$3.7M
Dendritic upconverting nanoparticles for multiphoton imaging and sensingR01EB018464 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2014 to 2017
$1.5M
Host-microbial interactions in the gut oxygen equilibriumR01GM103591 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WU, GARY D. · 2013 to 2016
$1.3M
Enabling widespread use of high resolution imaging of oxygen in the brainR24NS092986 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BOAS, DAVID A, VINOGRADOV, SERGEI · 2015 to 2018
$1.2M
NCI NIH HHS T32 CA009140NIAID NIH HHS R01 AI118891NIBIB NIH HHS R01 EB018464NIDDK NIH HHS P30 DK050306NIEHS NIH HHS P30 ES013508NIEHS NIH HHS P42 ES023720NIGMS NIH HHS R01 GM080279NIGMS NIH HHS R01 GM103591NINDS NIH HHS R24 NS092986
6 · The paper itself

Abstract

The succession from aerobic and facultative anaerobic bacteria to obligate anaerobes in the infant gut along with the differences between the compositions of the mucosally adherent vs. luminal microbiota suggests that the gut microbes consume oxygen, which diffuses into the lumen from the intestinal tissue, maintaining the lumen in a deeply anaerobic state. Remarkably, measurements of luminal oxygen levels show nearly identical pO

Indexed as

AnaerobiosisGastrointestinal MicrobiomeAnimalsBacteria, AnaerobicComputer SystemsGastric MucosaGastrointestinal ContentsGerm-Free LifeIntestinal MucosaLipidsLuminescent MeasurementsMetalloporphyrinsMiceMice, Inbred C57BLOxidation-ReductionOxygenLipidsMetalloporphyrinsOxygenoxyphor G4Proteinsgut microbiotaluminal oxygenmicrobial ecologyoxygen probesphosphorescence quenching

Identifiers

PMID29610310
PMCPMC5910840
OpenAlexW2795852373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.