Evidence map›Paper›PMID 29610307›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Complete biosynthesis of noscapine and halogenated alkaloids in yeast.

Yanran Li, Sijin Li, Kate Thodey, Isis Trenchard, Aaron Cravens, Christina D Smolke

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 284 citations in OpenAlex.

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  16. Synthetic and systems biotechnology · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Synthetic biology in plants.Plant biotechnology (Tokyo, Japan) · 2024
    Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yanran LiDepartment of Chemical and Environmental Engineering, University of California, Riverside, CA 92521.
Sijin LiDepartment of Bioengineering, Stanford University, Stanford, CA 94305.
Kate ThodeyAntheia Inc., Menlo Park, CA 94025.
Isis TrenchardAntheia Inc., Menlo Park, CA 94025.
Aaron CravensDepartment of Bioengineering, Stanford University, Stanford, CA 94305.
Christina D SmolkeDepartment of Bioengineering, Stanford University, Stanford, CA 94305; csmolke@stanford.edu.
Menlo School · USStanford University · USChan Zuckerberg Initiative (United States) · USUniversity of California, Riverside · US

Funding

Synthetic Biology Platforms for Natural Product Discovery and BiosynthesisDP1AT007886 · NCCIH · STANFORD UNIVERSITY · PI SMOLKE, CHRISTINA D · 2012 to 2016
$3.9M
NCCIH NIH HHS DP1 AT007886
6 · The paper itself

Abstract

Microbial biosynthesis of plant natural products from simple building blocks is a promising approach toward scalable production and modification of high-value compounds. The pathway for biosynthesis of noscapine, a potential anticancer compound, from canadine was recently elucidated as a 10-gene cluster from opium poppy. Here we demonstrate the de novo production of noscapine in

Indexed as

Metabolic EngineeringHydrocarbons, HalogenatedNoscapineSaccharomyces cerevisiaeHydrocarbons, HalogenatedNoscapinebenzylisoquinoline alkaloidsmetabolic engineeringplant alkaloidsSaccharomyces cerevisiae

Identifiers

PMID29610307
PMCPMC5924921
OpenAlexW2795396508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.