Evidence map›Paper›PMID 29610276›Full record

ArticleThe Journal of biological chemistry2018

The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells.

Anna R Roy, Abdalla Ahmed, Peter V DiStefano, Lijun Chi, Nadiya Khyzha, Niels Galjart, Michael D Wilson, Jason E Fish, Paul Delgado-Olguín

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Mouse Genotyping.Methods in molecular biology (Clifton, N.J.) · 2026
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  13. Molecular cancer research : MCR · 2019
    Article
  14. Developing in 3D: the role of CTCF in cell differentiation.Development (Cambridge, England) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anna R RoyFrom the Translational Medicine Research Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Abdalla AhmedFrom the Translational Medicine Research Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Peter V DiStefanoToronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
Lijun ChiFrom the Translational Medicine Research Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Nadiya KhyzhaToronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
Niels GaljartDepartment of Cell Biology and Genetics, Erasmus Medical Center, Rotterdam 3015 CN, The Netherlands.
Michael D WilsonDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Jason E FishToronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
Paul Delgado-OlguínFrom the Translational Medicine Research Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada, paul.delgadoolguin@sickkids.ca.ORCID 0000-0002-5355-247X
University of Toronto · CAUniversity Health Network · CAErasmus MC · NLHospital for Sick Children · CA

Funding

CIHR MOP-119506CIHR PJT-149046
6 · The paper itself

Abstract

The CCCTC-binding factor (CTCF) is a versatile transcriptional regulator required for embryogenesis, but its function in vascular development or in diseases with a vascular component is poorly understood. Here, we found that endothelial Ctcf is essential for mouse vascular development and limits accumulation of reactive oxygen species (ROS). Conditional knockout of

Indexed as

Gene Expression RegulationOxidative StressAnimalsCCCTC-Binding FactorCells, CulturedEmbryo, MammalianEndothelium, VascularFemaleFrataxinFriedreich AtaxiaHumansHuman Umbilical Vein Endothelial CellsIron-Binding ProteinsMaleMiceMice, KnockoutCCCTC-Binding FactorCtcf protein, mouseFrataxinIron-Binding ProteinsReactive Oxygen SpeciesCTCFdevelopmentembryoendothelial cellfrataxinFriedreich's ataxiagene expressiongene regulationoxidative stressplacentareactive oxygen species (ROS)vascularvascular biology

Identifiers

PMID29610276
PMCPMC5986204
OpenAlexW2796142446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.