Evidence map›Paper›PMID 29610265›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2018

Preconception Blood Pressure Levels and Reproductive Outcomes in a Prospective Cohort of Women Attempting Pregnancy.

Carrie J Nobles, Pauline Mendola, Sunni L Mumford, Ashley I Naimi, Edwina H Yeung, Keewan Kim, Hyojun Park, Brian Wilcox, Robert M Silver, Neil J Perkins and 2 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00467363 (The Effects of Aspirin in Gestation and Reproduction), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00467363 nacompletednot on this map

The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2007 to 2012Enrolled1,228ConditionsBirth, Spontaneous AbortionArmsacetylsalicylic-acid (aspirin), Folic acid
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
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  6. Article
  7. Review
  8. Review
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  14. Article
  15. Phenotype-Directed Management of Hypertension in Pregnancy.Journal of the American Heart Association · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Visit-to-visit blood pressure variability and risk of adverse birth outcomes in pregnancies in East China.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Carrie J NoblesFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Pauline MendolaFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Sunni L MumfordFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Ashley I NaimiFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Edwina H YeungFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Keewan KimFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Hyojun ParkFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Brian WilcoxFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Robert M SilverFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Neil J PerkinsFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Lindsey SjaardaFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
Enrique F SchistermanFrom the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.). schistee@mail.nih.gov.
University of Pittsburgh · USCommonwealth Medical College · US

Funding

EAGeR Trial - The Effects of Aspirin in Gestation and Reproduction TrialZIAHD008795 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PERKINS, NEIL · 2009 to 2025
$9.6M
Estimating the Effect of Low-Dose Aspirin on Fetal Loss in a Trial with Non-ComplianceR01HD093602 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAIMI, ASHLEY ISAAC · 2018 to 2021
$1.2M
EAGeR Trial - The Effects of Aspirin in Gestation and Reproduction TrialZ01HD008795 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SCHISTERMAN, ENRIQUE · 2007 to 2008
$596k
Intramural NIH HHS Z01 HD008795NICHD NIH HHS R01 HD093602
6 · The paper itself

Abstract

Elevated blood pressure in young adulthood is an early risk marker for cardiovascular disease. Despite a strong biological rationale, little research has evaluated whether incremental increases in preconception blood pressure have early consequences for reproductive health. We evaluated preconception blood pressure and fecundability, pregnancy loss, and live birth in the EAGeR trial (Effects of Aspirin on Gestational and Reproduction; 2007-2011), a randomized clinical trial of aspirin and reproductive outcomes among 1228 women attempting pregnancy with a history of pregnancy loss. Systolic and diastolic blood pressure were measured during preconception in the first observed menstrual cycle and in early pregnancy and used to derive mean arterial pressure. Fecundability was assessed as number of menstrual cycles until pregnancy, determined through human chorionic gonadotropin testing. Pregnancy loss included both human chorionic gonadotropin-detected and clinical losses. Analyses adjusted for treatment assignment, age, body mass index, race, marital status, smoking, parity, and time since last loss. Mean preconception systolic and diastolic blood pressure were 111.6 mm Hg (SD, 12.1) and 72.5 (SD, 9.4) mm Hg. Risk of pregnancy loss increased 18% per 10 mm Hg increase in diastolic blood pressure (95% confidence interval, 1.03-1.36) and 17% per 10 mm Hg increase in mean arterial pressure (95% confidence interval, 1.02-1.35) in adjusted analyses. Findings were similar for early pregnancy blood pressure. Preconception blood pressure was not related to fecundability or live birth in adjusted analyses. Findings suggest that preconception blood pressure among healthy women is associated with pregnancy loss, and lifestyle interventions targeting blood pressure among young women may favorably impact reproductive health. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00467363.

Indexed as

Pregnancy OutcomeAbortion, SpontaneousAdultAspirinBlood PressureBlood Pressure DeterminationCohort StudiesFemaleFertilityHumansHypertensionLive BirthPreconception CarePregnancyPregnancy, High-RiskProspective StudiesAspirinabortion, spontaneousblood pressurepregnancyreproductive health

Identifiers

PMID29610265
PMCPMC5897130
OpenAlexW2794481229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.