Evidence map›Paper›PMID 29610141›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Altered Ratio of T Follicular Helper Cells to T Follicular Regulatory Cells Correlates with Autoreactive Antibody Response in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Wenjin Fan, Andrew James Demers, Yanmin Wan, Qingsheng Li

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Galectin-8 deficiency promotes chronic splenomegaly persistence in Chagas disease.Frontiers in cellular and infection microbiology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Follicular regulatory T cells: a novel target for immunotherapy?Clinical & translational immunology · 2020
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wenjin FanNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583; and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583.
Andrew James DemersNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583; and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583.
Yanmin WanNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583; and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583.
Qingsheng LiNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583; and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583 qli@unl.edu.ORCID 0000-0003-4101-4073
University of Nebraska–Lincoln · US

Funding

Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
NEBRASKA CENTER FOR VIROLOGY: AIDSP30RR031151 · NCRR · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2010 to 2011
$2.9M
The Early Events Determining SIV Rectal TransmissionR01DK087625 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI LI, QINGSHENG · 2010 to 2013
$1.4M
NCRR NIH HHS P30 RR031151NIDDK NIH HHS R01 DK087625NIGMS NIH HHS P30 GM103509
6 · The paper itself

Abstract

Individuals with chronic HIV-1 infection have an increased prevalence of autoreactive Abs. Many of the isolated HIV broadly neutralizing Abs from these individuals are also autoreactive. However, the underlying mechanism(s) that produce these autoreactive broadly neutralizing Abs remains largely unknown. The highly regulated coordination among B cells, T follicular helper (T

Indexed as

AnimalsAutoantibodiesGerminal CenterMacaca mulattaSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryAutoantibodies

Identifiers

PMID29610141
PMCPMC6026535
OpenAlexW2795827890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.