Evidence map›Paper›PMID 29609894›Full record

ReviewTrends in cognitive sciences2018

Interpreting and Utilising Intersubject Variability in Brain Function.

Mohamed L Seghier, Cathy J Price

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. The nonlinear trajectory of post-stroke aphasia recovery.Frontiers in human neuroscience · 2026
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mohamed L SeghierCognitive Neuroimaging Unit, Emirates College for Advanced Education, PO Box 126662, Abu Dhabi, United Arab Emirates. Electronic address: mseghier@gmail.com.
Cathy J PriceWellcome Centre for Human Neuroimaging, University College London, Institute of Neurology, WC1N 3BG, London, UK. Electronic address: c.j.price@ucl.ac.uk.

Funding

Medical Research Council MR/M023672/1Wellcome TrustWellcome Trust 097720/Z/11/ZWellcome Trust 205103/Z/16/Z
6 · The paper itself

Abstract

We consider between-subject variance in brain function as data rather than noise. We describe variability as a natural output of a noisy plastic system (the brain) where each subject embodies a particular parameterisation of that system. In this context, variability becomes an opportunity to: (i) better characterise typical versus atypical brain functions; (ii) reveal the different cognitive strategies and processing networks that can sustain similar tasks; and (iii) predict recovery capacity after brain damage by taking into account both damaged and spared processing pathways. This has many ramifications for understanding individual learning preferences and explaining the wide differences in human abilities and disabilities. Understanding variability boosts the translational potential of neuroimaging findings, in particular in clinical and educational neuroscience.

Indexed as

Biological Variation, IndividualIndividualityBrainHumansbrain structurecognitive strategiescovariancefunctional variabilityindividualised predictionsneuroimaging

Identifiers

PMID29609894
PMCPMC5962820

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.