ArticleBMC genomics2018
A high-resolution genetic linkage map and QTL fine mapping for growth-related traits and sex in the Yangtze River common carp (Cyprinus carpio haematopterus).
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 66 citations in OpenAlex.
- Genetic diversity and population structure of the native grass carp (Ctenopharyngodon idella) from the Xiangjiang River revealed by microsatellite markers.Journal of fish biology · 2026Article
- Identification of Genes Related to Rapid Growth of Giant Grouper (Animals : an open access journal from MDPI · 2025Article
- Special Issue: Molecular Advance on Reproduction and Fertility of Aquatic Animals.International journal of molecular sciences · 2024Article
- Optimizing reproductive performance in pangasius catfish broodstock: A review of dietary and molecular strategies.Veterinary and animal science · 2024Review
- Analysis of Chromatin Accessibility and DNA Methylation to Reveal the Functions of Epigenetic Modifications inInternational journal of molecular sciences · 2023Article
- Construction of a high-density genetic linkage map and QTL mapping of growth and cold tolerance traits in Takifugu fasciatus.BMC genomics · 2023Article
- Age-Dependent Growth-Related QTL Variations in Pacific Abalone,International journal of molecular sciences · 2023Article
- Chromosome-scale assembly and quantitative trait locus mapping for major economic traits of theFrontiers in genetics · 2023Article
- Linkage mapping and QTL analysis of growth traits in Rhopilema esculentum.Scientific reports · 2022Article
- First genetic maps development and QTL mining inFrontiers in plant science · 2022Article
- A High-Density Genetic Map and QTL Fine Mapping for Growth- and Sex-Related Traits in Red Swamp Crayfish (Frontiers in genetics · 2022Article
- Construction of Three High-Density Genetic Linkage Maps and Dynamic QTL Mapping of Growth Traits in Yellow River Carp (Current issues in molecular biology · 2021Article
- Updated Genome Assembly of Bighead Carp (Frontiers in genetics · 2021Article
- A high-density SNP-based genetic map and several economic traits-related loci in Pelteobagrus vachelli.BMC genomics · 2020Article
- First High-Density Linkage Map and QTL Fine Mapping for Growth-Related Traits of Spotted Sea bass (Lateolabrax maculatus).Marine biotechnology (New York, N.Y.) · 2020Article
- ddRADseq-assisted construction of a high-density SNP genetic map and QTL fine mapping for growth-related traits in the spotted scat (Scatophagus argus).BMC genomics · 2020Article
- QTL Fine Mapping for Sex Determination Region in Bighead Carp (Hypophthalmichthys nobilis) and Comparison with Silver Carp (Hypophthalmichthys molitrix).Marine biotechnology (New York, N.Y.) · 2020Article
- Genetic analysis of body weight in wild populations of medaka fish from different latitudes.PloS one · 2020Article
- Multiple interacting QTLs affect disease challenge survival in common carp (Cyprinus carpio).Heredity · 2019Article
- Characterization and analysis of the transcriptome in Gymnocypris selincuoensis on the Qinghai-Tibetan Plateau using single-molecule long-read sequencing and RNA-seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
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Abstract
backgroundA high-density genetic linkage map is essential for QTL fine mapping, comparative genome analysis, identification of candidate genes and marker-assisted selection for economic traits in aquaculture species. The Yangtze River common carp (Cyprinus carpio haematopterus) is one of the most important aquacultured strains in China. However, quite limited genetics and genomics resources have been developed for genetic improvement of economic traits in such strain.
resultsA high-resolution genetic linkage map was constructed by using 7820 2b-RAD (2b-restriction site-associated DNA) and 295 microsatellite markers in a F2 family of the Yangtze River common carp (C. c. haematopterus). The length of the map was 4586.56 cM with an average marker interval of 0.57 cM. Comparative genome mapping revealed that a high proportion (70%) of markers with disagreed chromosome location was observed between C. c. haematopterus and another common carp strain (subspecies) C. c. carpio. A clear 2:1 relationship was observed between C. c. haematopterus linkage groups (LGs) and zebrafish (Danio rerio) chromosomes. Based on the genetic map, 21 QTLs for growth-related traits were detected on 12 LGs, and contributed values of phenotypic variance explained (PVE) ranging from 16.3 to 38.6%, with LOD scores ranging from 4.02 to 11.13. A genome-wide significant QTL (LOD = 10.83) and three chromosome-wide significant QTLs (mean LOD = 4.84) for sex were mapped on LG50 and LG24, respectively. A 1.4 cM confidence interval of QTL for all growth-related traits showed conserved synteny with a 2.06 M segment on chromosome 14 of D. rerio. Five potential candidate genes were identified by blast search in this genomic region, including a well-studied multi-functional growth related gene, Apelin.
conclusionsWe mapped a set of suggestive and significant QTLs for growth-related traits and sex based on a high-density genetic linkage map using SNP and microsatellite markers for Yangtze River common carp. Several candidate growth genes were also identified from the QTL regions by comparative mapping. This genetic map would provide a basis for genome assembly and comparative genomics studies, and those QTL-derived candidate genes and genetic markers are useful genomic resources for marker-assisted selection (MAS) of growth-related traits in the Yangtze River common carp.
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