Evidence map›Paper›PMID 29609464›Full record

ArticleBiochemistry2018

Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor.

Hannah R Rose, Manas K Ghosh, Ailiena O Maggiolo, Christopher J Pollock, Elizabeth J Blaesi, Viviane Hajj, Yifeng Wei, Lauren J Rajakovich, Wei-Chen Chang, Yilin Han and 6 more

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. OJournal of the American Chemical Society · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Radicals in Biology: Your Life Is in Their Hands.Journal of the American Chemical Society · 2021
    Article
  14. A ribonucleotide reductase fromThe Journal of biological chemistry · 2020
    Article
  15. Article
  16. The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  17. Article
  18. Article
  19. Class Id ribonucleotide reductase utilizes a MnJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019
    Article
  20. Redox-induced structural changes in the di-iron and di-manganese forms of Bacillus anthracis ribonucleotide reductase subunit NrdF suggest a mechanism for gating of radical access.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Hannah R Rose
Manas K Ghosh
Ailiena O Maggiolo
Christopher J PollockORCID 0000-0001-5736-513X
Elizabeth J Blaesi
Viviane Hajj
Yifeng WeiDepartment of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Lauren J Rajakovich
Yilin Han
Mariana Hajj
Maria-Eirini PandeliaDepartment of Biochemistry , Brandeis University , Waltham , Massachusetts 02454 , United States.
J Martin BollingerORCID 0000-0003-0751-8585
Pennsylvania State University · USBrandeis University · USMassachusetts Institute of Technology · US

Funding

Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
Functional diversification of the HD-superfamily; the Hydrolase/Oxygenase DilemmaR00GM111978 · NIGMS · BRANDEIS UNIVERSITY · PI PANDELIA, MARIA-EIRINI · 2016 to 2018
$740k
Structure determination of reaction intermediates in macromolecular complexesR00GM100011 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOAL, AMIE K · 2013 to 2015
$729k
Mechanistic Determination of the Non-heme Iron Enzyme Hyoscyamine-6-hydroxylaseF32GM113389 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI POLLOCK, CHRISTOPHER · 2015 to 2017
$160k
Mechanisms of Radical Translocation in Class I Ribonucleotide ReductasesF32GM116353 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BLAESI, ELIZABETH J · 2015 to 2017
$160k
Structure determination of reaction intermediates in macromolecular complexesK99GM100011 · NIGMS · NORTHWESTERN UNIVERSITY · PI BOAL, AMIE K · 2012 to 2013
$110k
Functional diversification of the HD-superfamily; the Hydrolase/Oxygenase DilemmaK99GM111978 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PANDELIA, MARIA-EIRINI · 2014 to 2015
$107k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM113389NIGMS NIH HHS F32 GM116353NIGMS NIH HHS K99 GM100011NIGMS NIH HHS K99 GM111978NIGMS NIH HHS R00 GM100011NIGMS NIH HHS R00 GM111978NIGMS NIH HHS R35 GM119707NIH HHS S10 OD012289
6 · The paper itself

Abstract

A ribonucleotide reductase (RNR) from Flavobacterium johnsoniae ( Fj) differs fundamentally from known (subclass a-c) class I RNRs, warranting its assignment to a new subclass, Id. Its β subunit shares with Ib counterparts the requirements for manganese(II) and superoxide (O

Indexed as

CatalysisCatalytic DomainFlavobacteriumFlavoproteinsIronManganeseOxidation-ReductionOxygenRibonucleotide ReductasesSuperoxidesTyrosineFlavoproteinsIronManganeseOxygenRibonucleotide ReductasesSuperoxidesTyrosine

Identifiers

PMID29609464
PMCPMC6488936
OpenAlexW2796366830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.