ArticleAnnals of pediatric endocrinology & metabolism2018
Design of the long-term observational cohort study with recombinant human growth hormone in Korean children: LG Growth Study.
Article in Annals of pediatric endocrinology & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Growth Hormone Treatment Response and Machine Learning-Based Prediction in Idiopathic GHD and ISS: Analysis of the Korean LG Growth Study.Clinical endocrinology · 2026Observational
- Pituitary magnetic resonance imaging abnormalities and 1-year growth response in children with idiopathic growth hormone deficiency.Annals of pediatric endocrinology & metabolism · 2026Article
- Accumulated safety data of recombinant human growth hormone therapy in Korean children over a 10-year period: interim results from the LG Growth Study.Endocrine connections · 2026Article
- Long-Term experience with growth hormone therapy in pediatric growth disorders: an analysis of the LG growth study data.Endocrine · 2026Observational
- Elevated IGF-1 levels are associated with accelerated bone age advancement during growth hormone therapy in children: a multicenter cohort study.Frontiers in endocrinology · 2026Observational
- Impact of COVID-19 on growth hormone therapy efficacy in pediatric patients with short stature.Endocrine connections · 2025Article
- Adiposity Rebound Timing in Small for Gestational Age Children Treated With Growth Hormone: Results From LG Growth Study Data.Journal of Korean medical science · 2025Observational
- Article
- Metabolic changes after growth hormone treatment in children with growth hormone deficiency and small for gestational age: LG observational study.Frontiers in endocrinology · 2025Observational
- Response of children with Turner syndrome with different types of karyotype abnormalities to growth hormone treatment.Annals of pediatric endocrinology & metabolism · 2024Article
- Development and validation of a nomogram to predict poor short-term response to recombinant human growth hormone treatment in children with growth disorders.Journal of endocrinological investigation · 2023Article
- Growth Responses During 3 Years of Growth Hormone Treatment in Children and Adolescents With Growth Hormone Deficiency: Comparison Between Idiopathic, Organic and Isolated Growth Hormone Deficiency, and Multiple Pituitary Hormone Deficiency.Journal of Korean medical science · 2022Article
- Response to growth hormone according to provocation test results in idiopathic short stature and idiopathic growth hormone deficiency.Annals of pediatric endocrinology & metabolism · 2022Article
- Association between uric acid and height during growth hormone therapy in children with idiopathic short stature.Frontiers in endocrinology · 2022Article
- Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data.PloS one · 2022Article
- Long-term GH Therapy Does Not Advance Skeletal Maturation in Children and Adolescents.Journal of the Endocrine Society · 2021Article
- Article
- Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.PloS one · 2021Article
- Predicting First-Year Growth in Response to Growth Hormone Treatment in Prepubertal Korean Children with Idiopathic Growth Hormone Deficiency: Analysis of Data from the LG Growth Study Database.Journal of Korean medical science · 2020Article
- Observational
Corrections and comments
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Authors and funding
10 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRegarding recombinant human growth hormone (rhGH) use in the pediatric population, no long-term follow-up data are available for Korean patients. To fill in the gap of knowledge, a registry study (LG Growth Study) was initiated to assess the safety and effectiveness of four types of rhGH products in real-life settings.
methodsA total of 4,000 children will be registered and prospectively followed up at 6-month intervals until 2 years after epiphyseal closure to collect data on treatment and adverse events, with primary interest in malignancies and growth outcomes.
resultsAs of 22 March 2017, approximately 50% (2,024) of the target number of patients have been included in the analysis set: growth hormone deficiency, 1,297 (64.1%); idiopathic short stature, 315 (15.6%); small for gestational age, 206 (10.2%); Turner syndrome, 197 (9.7%); and chronic renal failure, 9 (0.4%). At baseline, median age (years) was 8 (interquartile range [IQR], 5-11); 52% (1,048) were boys; and the majority were at Tanner stage I (83% based on breast/external genitalia, 97% on pubic hair). Median height standard deviation score was -2.26 (IQR, -2.69 to -2.0), and median bone age delay (years) was -1.46 (IQR, -2.26 to -0.78).
conclusionsThis registry study will provide the opportunity to assess the risk of malignancies as well as the general safety data in Korean pediatric patients receiving rhGH. In addition, the long-term effectiveness of rhGH and comparative data between different disease entities will provide practical insight on the standard rhGH treatment.
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